ArticleBritish journal of pharmacology2019
Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Activity-restoring mutations in the histamine HProtein science : a publication of the Protein Society · 2026Article
- Investigating Endogenous Opioids Unravels the Mechanisms Behind Opioid-Induced Constipation, a Mathematical Modeling Approach.International journal of molecular sciences · 2025Article
- A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation.British journal of pharmacology · 2025Article
- Effects of pH on opioid receptor activation and implications for drug design.Biophysical journal · 2024Review
- Advances in yeast synthetic biology for human G protein-coupled receptor biology and pharmacology.Current opinion in biotechnology · 2024Review
- Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design.Scientific reports · 2023Article
- Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP.Frontiers in molecular neuroscience · 2023Article
- Fentanyl but Not Morphine or Buprenorphine Improves the Severity of Necrotizing Acute Pancreatitis in Rats.International journal of molecular sciences · 2022Article
- Article
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs.International journal of molecular sciences · 2021Review
- Article
- How μ-opioid receptor recognizes fentanyl.Nature communications · 2021Article
- HowbioRxiv : the preprint server for biology · 2020Article
- How mu-Opioid Receptor Recognizes Fentanyl.Research square · 2020Article
- Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.British journal of pharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAdverse side effects of conventional opioids can be avoided if ligands selectively activate peripheral opioid receptors in injured tissue. Injury and inflammation are typically accompanied by acidification. In this study, we examined influences of low pH and mutation of the ionizable amino acid residue H297 EXPERIMENTAL APPROACH: HEK 293 cells stably transfected with μ-opioid receptors were used to study opioid ligand binding, [ KEY
resultsLow pH and the mutant receptor MOR-H297 CONCLUSIONS AND IMPLICATIONS: Our investigations indicate that low pH selectively impairs μ-opioid receptor signalling modulated by ligands capable of forming hydrogen bonds with H297
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