Evidence map›Paper›PMID 31355374›Full record

ArticleQualitative report (Online)2018

Medication Exposure Patterns in Primary Care Patients Prescribed Pharmacogenetically Actionable Opioids.

Mitchell R Knisely, Janet S Carpenter, Marion E Broome, Ann M Holmes, Diane Von Ah, Todd Skaar, Claire Burke Draucker

Open access · goldAbstract read
In one paragraph

Article in Qualitative report (Online), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. A systematic review of real-world evidence on the clinical relevance, characterization, and utility ofJournal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mitchell R KniselyDuke University, Durham, North Carolina, USA.
Janet S CarpenterIndiana University, Indianapolis, Indiana, USA.
Marion E BroomeDuke University, Durham, North Carolina, USA.
Ann M HolmesIndiana University, Indianapolis, Indiana, USA.
Diane Von AhIndiana University, Indianapolis, Indiana, USA.
Todd SkaarIndiana University, Indianapolis, Indiana, USA.
Claire Burke DrauckerIndiana University, Indianapolis, Indiana, USA.
Indiana University · USNova Southeastern University · USIndiana University – Purdue University Indianapolis · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
Embedding Pharmacogenotyping in an Integrated Health System for the UnderservedU01HG007762 · NHGRI · INDIANA UNIVERSITY INDIANAPOLIS · PI DEXTER, PAUL, SKAAR, TODD C. · 2014 to 2018
$4.4M
INDIANA UNIVERSITY: TRAINING IN BEHAVIORAL NURSINGT32NR007066 · NINR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RAWL, SUSAN M · 1990 to 2017
$4.2M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: NEUROLOGICAL DISORDERS:ALZ, PDC06RR020128 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FIFE, ROSE S · 2004 to 2004
$3.7M
NCATS NIH HHS UL1 TR001108NCRR NIH HHS C06 RR020128NHGRI NIH HHS U01 HG007762NINR NIH HHS T32 NR007066NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

Current approaches to assessing medication exposure fail to capture the complexity of the phenomenon and the context in which it occurs. This study's purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol. Data related to medication exposure were drawn from large data repositories. Using a person-oriented qualitative approach, eight subgroups of patients who shared common patterns of medication exposure were identified. The subgroups had one of five opioid prescription patterns (i.e., singular, episodic, switching, sustained, multiplex), and one of three types of primary foci of medical care (i.e., pain, comorbidities, both). The findings reveal medication exposure patterns that are dynamic, multidimensional, and complex, and the typology offers an innovative approach to assessing medication exposure.

Indexed as

Medication ExposureOpioidPain ManagementPerson-Oriented ApproachPharmacogenomics

Identifiers

PMID31355374
PMCPMC6660172
OpenAlexW2904109195

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.