Evidence map›Paper›PMID 31355322›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2019

Systemic inflammatory response syndrome and long-term outcome after intracerebral hemorrhage.

Manuel Hagen, Jochen A Sembill, Maximilian I Sprügel, Stefan T Gerner, Dominik Madžar, Hannes Lücking, Philip Hölter, Stefan Schwab, Hagen B Huttner, Joji B Kuramatsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Systemic inflammatory response syndrome and adverse outcomes in acute intracerebral hemorrhage: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  11. More severe initial manifestations and worse short-term functional outcome of intracerebral hemorrhage in the plateau than in the plain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Manuel HagenDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Jochen A SembillDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Maximilian I SprügelDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Stefan T GernerDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Dominik MadžarDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Hannes LückingDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Philip HölterDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.ORCID 0000-0001-9768-9630
Stefan SchwabDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Hagen B HuttnerDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Joji B KuramatsuDepartment of Neurology (M.H., J.A.S., M.I.S., S.T.G., D.M., S.S., H.B.H., J.B.K.) and Department of Neuroradiology (H.L., P.H.), University of Erlangen-Nuremberg, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate whether the systemic inflammatory response syndrome (SIRS) without infection as surrogate of a systemic immune response is associated with poor long-term functional outcome in patients with spontaneous intracerebral hemorrhage (ICH). Methods: We analyzed consecutive patients with spontaneous ICH from our prospective cohort study (2018-2015). SIRS was defined according to standard criteria: i.e., 2 or more of the following parameters during hospitalization: body temperature <36°C or >38°C, respiratory rate >20 per minute, heart rate >90 per minute, or white blood cell count <4,000/μL or >12,000/μL in the absence of infection. The primary outcome consisted of the modified Rankin Scale (mRS) at 3 and 12 months investigated by adjusted ordinal shift analyses. Bias and confounding were addressed by propensity score matching and multivariable regression models. Results: Of 780 patients with ICH, 21.8% (n = 170) developed SIRS during hospitalization. Patients with SIRS showed more severe ICH compared with those without; i.e., larger ICH volumes (18.3 cm Conclusions: In patients with ICH, we identified SIRS to be predictive of poorer long-term functional outcome over the entire range of mRS estimates. Clinically relevant associations with SIRS were documented for previous liver dysfunction and hematoma enlargement.

Indexed as

AgedAged, 80 and overCerebral HemorrhageCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRecovery of FunctionRetrospective StudiesSystemic Inflammatory Response SyndromeTime FactorsTreatment Outcome

Identifiers

PMID31355322
PMCPMC6624147
OpenAlexW2956104136

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.