ArticleNeurology(R) neuroimmunology & neuroinflammation2019
Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity.
Open access · goldAbstract read
In one paragraph
Article in Neurology(R) neuroimmunology & neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Role of Neutrophils on the Ocular Surface.International journal of molecular sciences · 2021Pooled it
- Effect of pre-infusion of hypertonic saline on postoperative delirium in geriatric patients undergoing shoulder arthroscopy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells.Clinical and experimental immunology · 2021Trial
- Neutrophil-Mimetic MRI Enables Ultra-Early Detection of Vascular Inflammation After Stroke.Advanced healthcare materials · 2026Article
- Systemic immune dysregulation and neutrophil activation define prognostic inflammatory signatures in drug-resistant epilepsy.JCI insight · 2026Article
- Neutrophil Heterogeneity: Molecules to Cellular Behavior.Life (Basel, Switzerland) · 2026Review
- Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke.Acta pharmacologica Sinica · 2026Review
- Targeting Neutrophil Extracellular Traps: A New Strategy for the Treatment of Acute Ischemic Stroke Based on Thrombolysis Resistance.Seminars in thrombosis and hemostasis · 2026Review
- Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function.Nature communications · 2025Article
- Harnessing smart nanomaterials to reprogram neutrophil plasticity in immune modulation.Journal of nanobiotechnology · 2025Review
- Spatiotemporal regulation of neutrophil heterogeneity in health and disease.Human molecular genetics · 2025Review
- Identification and Validation of Glycosylation‑Related Genes in Ischemic Stroke Based on Bioinformatics and Machine Learning.Journal of molecular neuroscience : MN · 2025Article
- Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice.Translational stroke research · 2025Article
- The Aging Immune System: A Critical Attack on Ischemic Stroke.Molecular neurobiology · 2025Review
- Explainable machine learning model for predicting the outcome of acute ischemic stroke after intravenous thrombolysis.Frontiers in neurology · 2025Article
- Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy.Thrombosis journal · 2024Article
- Effects of peripheral blood cells on ischemic stroke: Greater immune response or systemic inflammation?Heliyon · 2024Review
- The Role of Neutrophils in Multiple Sclerosis and Ischemic Stroke.Brain sciences · 2024Review
- Potential Protein Signatures for Recurrence Prediction of Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Association of Gut Microbiome with Early Brain Injury After Subarachnoid Hemorrhage: an Experimental Study.Translational stroke research · 2024Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
David Weisenburger-LileSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Yuan DongSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Marion YgerSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Gaëlle WeisenburgerSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Giulia Frasca PolaraSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Thomas ChaigneauSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Riccardo Zapata OchoaSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Beatrice MarroSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Bertrand LapergueSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Sonia AlamowitchSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Carole ElbimSorbonne Universités (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine; INSERM (D.W.-L., Y.D., T.C., R.Z.O., S.A., C.E.), UMRS 938, CdR Saint- Antoine, Team "Immune System, Neuroinflammation and Neurodegenerative Diseases," Hôpital St-Antoine; Service de Neurologie et d'Urgences Neurovasculaires (D.W.-L., M.Y., S.A.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Division of Pneumology (G.W.), Foch Hospital, F-92150, Suresnes; Division of Neurology (G.F.P.), Stroke Center, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital; Division of Radiology (B.M.), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; and Division of Neurology (B.L.), Stroke Center, Foch Hospital, F-92150, Suresnes.
Inserm · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To better understand the functional state of circulating neutrophils in patients with ischemic stroke (IS) for planning future clinical trials. Methods: We analyzed by flow cytometry activation state of circulating neutrophils and the distribution of neutrophil peripheral subsets in 41 patients with acute IS less than 6 hours before admission and compared them with 22 age-matched healthy controls. Results: Our results demonstrated continuous basal hyperactivation of circulating neutrophils during acute IS, characterized by lower l-selectin expression and higher CD11b expression at the cell surface, increased ROS production by neutrophils, and greater circulating levels of neutrophil elastase. Neutrophil hyperactivation was associated with deregulation of the equilibrium between apoptotic and necrotic. Patients also had higher percentages than controls of the overactive senescent (CXCR4 Conclusion: Altogether, our results indicate that during acute IS, the inflammatory properties of circulating neutrophils rise, associated with the expansion of harmful neutrophil subsets. These changes in neutrophil homeostasis, associated with disease severity, may play an instrumental role by contributing to systemic inflammation and to the blood-brain barrier breakdown. Our findings highlight new potential therapeutic approaches of stroke by rebalancing the ratio of senescent to immunosuppressive neutrophils or decreasing reverse neutrophil transmigration or both.
Indexed as
AdultAgedAged, 80 and overAgingBrain IschemiaCD11b AntigenCell Adhesion MoleculesCell DeathCytokinesFemaleHealthy VolunteersHumansImmunosuppression TherapyInflammationLeukocyte ElastaseLongitudinal StudiesCD11b AntigenCell Adhesion MoleculesCytokinesITGAM protein, humanLeukocyte ElastaseL-SelectinReactive Oxygen SpeciesSELL protein, human
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