SynthesisNeurology(R) neuroimmunology & neuroinflammation2019
Immunoglobulin G4-related hypertrophic pachymeningitis: A case-oriented review.
Synthesis in Neurology(R) neuroimmunology & neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- IgG4-related spinal hypertrophic pachymeningitis: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Article
- IgG4-Related Disease Manifested as Hypertrophic Pachymeningitis: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Surgical management of recurrent spinal hypertrophic pachymeningitis: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Immunoglobulin G4 biomarkers and pathogenesis in immunoglobulin G4-related spinal pachymeningitis.World journal of clinical cases · 2025Article
- IgG4-Related Disease in Childhood: Clinical Presentation, Management, and Diagnostic Challenges.Children (Basel, Switzerland) · 2025Review
- Idiopathic hypertrophic pachymeningitis (IHP) causing headache in a young female.Ghana medical journal · 2025Article
- Intracranial Immunoglobulin G4-Related Disease Presented as Hypophysitis and Pachymeningitis: A Case Report.Journal of the Korean Society of Radiology · 2025Article
- A Rare Presentation of a Spinal Lesion: Immunoglobulin G4-Related Hypertrophic Spinal Pachymeningitis.Cureus · 2025Article
- Identifying global trends from case reports of fibrodysplasia ossificans progressiva: a scoping review.Therapeutic advances in musculoskeletal disease · 2025Article
- Intrathecal IgG4 synthesis in IgG4 related spinal hypertrophic pachymeningitis: a case report.Neurological research and practice · 2024Article
- A case of IgG4-related disease manifesting as a spinal epidural mass.BJR case reports · 2024Article
- A case report of Immunoglobulin-G4-related hypertrophic sclerosing pachymeningitis.Radiology case reports · 2024Article
- Immunoglobulin G4-related hypertrophic pachymeningitis with an isolated scalp mass mimicking a brain tumor: a case report and literature review.Journal of rheumatic diseases · 2024Article
- Cervical myelopathy caused by IgG4-related hypertrophic spinal pachymeningitis: Case report and a descriptive review of the literature.Brain & spine · 2024Article
- Treatment of IgG4-related disease-associated hypertrophic pachymeningitis with intrathecal rituximab: a case report.Frontiers in neurology · 2023Article
- Serum IgG4 level during initial treatment as a predictor of relapse in IgG4-related disease.PloS one · 2023Article
- Epiduritis related to IgG4 disease: A very rare cause for spinal cord compression.Surgical neurology international · 2023Article
- Pachymeningitis in Biopsy-Proven Sarcoidosis: Clinical Course, Radiographic Findings, Response to Treatment, and Long-term Outcomes.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions.Acta neurochirurgica · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Meningeal involvement in Immunoglobulin G (IgG)-4-related disease is rare and only described in case reports and series. Because a review into the disease is lacking, we present 2 cases followed by a literature review of IgG4-related hypertrophic pachymeningitis (IgG4-HP). Methods: Two IgG4-HP cases were reported, one involving the spinal cord and responding to surgical management and a second involving the brain and responding to Rituximab therapy. We then review clinical cases and case-series of histologically proven IgG4-HP that were published in the PubMed-NCBI database. Results: Forty-two case reports and 5 case-series were studied (60 patients, 20 women). The median age was 53. Eighteen patients had systemic involvement and 24 had single-organ IgG4-HP. Fifty-five percent of patients had an elevated serum IgG4. Treatment was surgical in 20/53 cases. Steroid therapy and immunosuppressors were effective in 85% and more than 90% of the cases, respectively. The rate of disease relapse was 42.1% after steroid therapy was discontinued. Discussion/conclusion: IgG4-HP is characterized by the lack of extra-neurologic organ-involvement and systemic signs. Histopathologic studies should be performed as it is crucial for diagnosis because serum markers are rarely informative. 18F-FDG positon tomography can be useful to characterize systemic forms. There is no specific CSF marker for IgG4-HP and the diagnostic value of CSF IgG4 levels needs to be studied with larger samples. We provide a treatment algorithm for IgG4-HP. Such treatment strategies rely on early surgery, steroids, and early immunosuppressive therapy to prevent neurologic complications.
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