Evidence map›Paper›PMID 31355297›Full record

ArticleJournal of immunology research2019

Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and

Anne Lise Ferrara, Fabiana Piscitelli, Angelica Petraroli, Roberta Parente, Maria Rosaria Galdiero, Gilda Varricchi, Giancarlo Marone, Massimo Triggiani, Vincenzo Di Marzo, Stefania Loffredo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Roles of Immune Cells in Hereditary Angioedema.Clinical reviews in allergy & immunology · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anne Lise FerraraDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.ORCID https://orcid.org/0000-0003-1839-8873
Fabiana PiscitelliEndocannabinoid Research Group, Istituto di Chimica Biomolecolare-Consiglio Nazionale delle Ricerche (ICB-CNR), Pozzuoli, Italy.ORCID https://orcid.org/0000-0001-9343-4622
Angelica PetraroliDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.ORCID https://orcid.org/0000-0001-5700-7164
Roberta ParenteDivision of Allergy and Clinical Immunology, University of Salerno, Italy.
Maria Rosaria GaldieroDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.ORCID https://orcid.org/0000-0002-8086-9130
Gilda VarricchiDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.ORCID https://orcid.org/0000-0002-9285-4657
Giancarlo MaroneDepartment of Public Health, University of Naples Federico II, Italy.ORCID https://orcid.org/0000-0003-0233-7830
Massimo TriggianiDivision of Allergy and Clinical Immunology, University of Salerno, Italy.ORCID https://orcid.org/0000-0001-7318-2093
Vincenzo Di MarzoEndocannabinoid Research Group, Istituto di Chimica Biomolecolare-Consiglio Nazionale delle Ricerche (ICB-CNR), Pozzuoli, Italy.ORCID https://orcid.org/0000-0002-1490-3070
Stefania LoffredoDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.ORCID https://orcid.org/0000-0002-5871-1898
University of Naples Federico II · ITUniversity of Salerno · ITFederico II University Hospital · ITInstitut universitaire de cardiologie et de pneumologie de Québec · CAIstituto di Chimica Biomolecolare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMastocytosis is a condition characterized by the expansion and accumulation of mast cells (MCs) in various organs. The symptoms are related to the increased release of MC-derived mediators that exert local and distant effects. MCs are a source and target of phospholipase enzymes (PLs), which catalyze the cleavage of membrane phospholipids releasing lipid mediators (e.g., diacylglycerols (DAGs) and the endocannabinoid (EC) 2-arachidonoylglycerol (2-AG)). To date, there are no data on the role of these lipid mediators in mastocytosis. Here, we analyzed plasma levels of PLA

methodsIn 23 patients with mastocytosis and 23 healthy individuals, we measured plasma PLA

resultsPlasma PLA

conclusionsPLs and some lipid mediators are altered in patients with mastocytosis. Our results may pave the way for investigating the functions of these mediators in the pathophysiology of mastocytosis and provide new potential biomarkers and therapeutic targets.

Indexed as

AdultAgedArachidonic AcidsBiomarkersDiglyceridesEndocannabinoidsEthanolaminesFemaleHumansMaleMastocytosisMiddle AgedPhospholipases A2Polyunsaturated AlkamidesTryptasesType C PhospholipasesanandamideArachidonic AcidsBiomarkersDiglyceridesEndocannabinoidsEthanolaminesN-acylethanolaminesPhospholipases A2Polyunsaturated AlkamidesTryptasesType C Phospholipases

Identifiers

PMID31355297
PMCPMC6636572
OpenAlexW2953696122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.