Evidence map›Paper›PMID 31355296›Full record

ArticleJournal of immunology research2019

STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis.

Carolina Prado, Valentina Ugalde, Hugo González, Alicia Figueroa, Ernesto López, Alvaro Lladser, Rodrigo Pacheco

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carolina PradoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Valentina UgaldeLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Hugo GonzálezLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Alicia FigueroaLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Ernesto LópezLaboratorio de Inmunoterapia Génica, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Alvaro LladserLaboratorio de Inmunoterapia Génica, Fundación Ciencia & Vida, Santiago 7780272, Chile.
Rodrigo PachecoLaboratorio de Neuroinmunología, Fundación Ciencia & Vida, Santiago 7780272, Chile.ORCID https://orcid.org/0000-0001-8057-9806
Fundación Ciencia and Vida · CLUniversidad Andrés Bello · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) have the ability to induce tolerance or inflammation in response to self-antigens, which makes them fundamental players in autoimmunity. In this regard, immunogenic DCs produce IL-12 and IL-23 favouring the acquisition of Th1 and Th17 inflammatory phenotypes, respectively, by autoreactive CD4

Indexed as

AnimalsArthritis, ExperimentalAutoimmunityCD4-Positive T-LymphocytesDendritic CellsHumansImmune ToleranceInflammationInterleukin-10Interleukin-12MaleMiceNF-kappa BSTAT3 Transcription FactorTh17 CellsTh1 CellsInterleukin-10Interleukin-12NF-kappa BSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID31355296
PMCPMC6636450
OpenAlexW2955622142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.