Evidence map›Paper›PMID 31355221›Full record

ArticleAnnals of translational medicine2019

Exosomes secreted by endothelial progenitor cells improve the bioactivity of pulmonary microvascular endothelial cells exposed to hyperoxia

Xiaomei Zhang, Aizhen Lu, Zhi Li, Jiali Sun, Dan Dai, Liling Qian

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
  3. Review
  4. Article
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Clinical applications of stem cell-derived exosomes.Signal transduction and targeted therapy · 2024
    Review
  11. Article
  12. Article
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaomei ZhangRespiratory Department, Children's Hospital of Fudan University, Shanghai 201102, China.
Aizhen LuRespiratory Department, Children's Hospital of Fudan University, Shanghai 201102, China.
Zhi LiThe Children's Hospital of Zhejiang University, School of Medicine, Hangzhou 310052, China.
Jiali SunRespiratory Department, Children's Hospital of Fudan University, Shanghai 201102, China.
Dan DaiRespiratory Department, Children's Hospital of Fudan University, Shanghai 201102, China.
Liling QianRespiratory Department, Children's Hospital of Fudan University, Shanghai 201102, China.
Children's Hospital of Fudan University · CNChildren's Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParacrine factors secreted by endothelial progenitor cells (EPCs) are suggested to be responsible, in part, for the improved microvascular development in bronchopulmonary dysplasia (BPD) models. This study aims to investigate the potential role of exosomes derived from EPCs (EPC-EXOs), a component of paracrine secretion, in angiogenesis by mediating the activity of PMVECs exposed to hyperoxia.

methodsEPCs were isolated from bone marrow of rats. EPC-EXOs were isolated by ExoQuick-TC kits from the conditioned media of EPCs. The PMVECs were divided into three groups, including the normal group, the hyperoxia group (exposed to 85% O

resultsWe found EPC-EXOs exhibited a cup or biconcave morphology, with the size ranging from 30 to 150 nm, and positive for the characteristic exosomal surface marker proteins, CD63 and TSG101. Comparing to the control group, Hyperoxic stress impaired the proliferation, migration, and tubule formation of PMVECs, and decreased the expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), and vascular endothelial growth factor receptor 2 (VEGFR-2) of PMVECs. Comparing to the hyperoxia group, EPC-EXOs treatment enhanced the bioactivity of PMVECs

conclusionsOur data demonstrate EPCs secrete exosomes that have independent angiogenic activity

Indexed as

Angiogenesisbronchopulmonary dysplasia (BPD)endothelial progenitor cells (EPCs)exosomespulmonary microvascular endothelial cells (PMVECs)

Identifiers

PMID31355221
PMCPMC6614332
OpenAlexW2947025946

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.