Evidence map›Paper›PMID 31355115›Full record

Review3 Biotech2019

Bioactive molecules of probiotic bacteria and their mechanism of action: a review.

M Indira, T C Venkateswarulu, K Abraham Peele, Md Nazneen Bobby, S Krupanidhi

Open access · bronzeAbstract readReview
In one paragraph

Review in 3 Biotech, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 138 citations in OpenAlex.

  1. Effect of PostbioticNutrients · 2024
    Trial
  2. Engineering the gut microbiome with metal-resistant bacteria could protect Artemia nauplii from cadmium toxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M IndiraDepartment of Bio-Technology, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India.
T C VenkateswaruluDepartment of Bio-Technology, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India.
K Abraham PeeleDepartment of Bio-Technology, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India.
Md Nazneen BobbyDepartment of Bio-Technology, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India.
S KrupanidhiDepartment of Bio-Technology, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India.
Vignan's Foundation for Science, Technology & Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bacteria residing in the gut environment do play a pivotal role in metabolic activities of the host. The metabolites produced by these bacteria affect the physiology and health of the host. The gut bacteria are exposed to environmental conditions where multiple factors such as lifestyle, stress, antibiotics, host genetics and infections have an influence on them. In case of pathogenesis of a disease, the gut bacterial composition is altered which leads to a diseased state. This stage is due to colonization of bacterial pathogens in the gut environment. The pathological condition can be alleviated by administering probiotic strains into the gut environment. The probiotic strains produce therapeutic molecules such as amino acids, vitamins, bacteriocins, enzymes, immunomodulatory compounds and short-chain fatty acids. This review discusses recent evidences of the impact of bioactive molecules produced by probiotic bacteria and their mechanism of action in the gut environment to maintain homeostasis and health of the host without any effect on beneficial bacteria sharing the same niche. In addition, the manufacturing challenges of probiotic products for various applications are discussed here.

Indexed as

BacteriocinMetabolitesPathogenesisProbioticShort-chain fatty acids

Identifiers

PMID31355115
PMCPMC6656846
OpenAlexW2964111984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.