Evidence map›Paper›PMID 31354881›Full record

ArticleCognitive neurodynamics2019

Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia.

Ting Xie, Qiongwei Li, Xingguang Luo, Li Tian, Zhiren Wang, Shuping Tan, Song Chen, Guigang Yang, Huimei An, Fude Yang and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cognitive neurodynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Variations to plasma HSchizophrenia (Heidelberg, Germany) · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Oxidative Stress and Emergence of Psychosis.Antioxidants (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Ting Xie1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Qiongwei Li1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Xingguang Luo2Department of Psychiatry, Yale University School of Medicine, New Haven, CT USA.
Li Tian3Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland.
Zhiren Wang1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Shuping Tan1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Song Chen1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Guigang Yang1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Huimei An1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Fude Yang1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Yunlong Tan1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, 100096 People's Republic of China.
Peking University · CNBeijing HuiLongGuan Hospital · CNUniversity of Helsinki · FIYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence suggest that excessive reactive oxygen species-induced oxidative damage may underlie neurodegeneration and cognitive impairment in several disorders including schizophrenia. In this study we examined the association of oxidative stress with cognitive deficits in first-episode drug-naïve (FEDN) patients with schizophrenia. We recruited 54 FEDN patients and 50 age- and sex-matched healthy controls and examined the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus cognitive Battery (MCCB) and plasma total antioxidant status (TAS). Psychopathological symptoms were assessed using the Positive and Negative Syndrome Scale. The results showed that plasma TAS levels were significantly lower in the patients than those in the healthy subjects (94.7 ± 25.0 U/ml vs 156.6 ± 46.7 U/ml,

Indexed as

Cognitive functionMCCBOxidative stressSchizophreniaTotal antioxidant capacity

Identifiers

PMID31354881
PMCPMC6624222
OpenAlexW2939777586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.