ArticleEvidence-based complementary and alternative medicine : eCAM2019
Network Pharmacology-Based Prediction and Verification of the Targets and Mechanism for Panax Notoginseng Saponins against Coronary Heart Disease.
Article in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Efficacy of Yangxin Recipe in Combination with Conventional Western Medicine in Treatment of Angina Pectoris of Coronary Heart Disease.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisTrial
- Medicinal Plants and Phytochemicals in Cardioprotection-Mechanistic Pathways and Translational Roadmap.Life (Basel, Switzerland) · 2026Review
- Potential therapeutic mechanisms ofFrontiers in pharmacology · 2025Review
- Network pharmacology analysis and clinical verification ofBiomedical reports · 2025Article
- A Comprehensive Review on Potential In Silico Screened Herbal Bioactive Compounds and Host Targets in the Cardiovascular Disease Therapy.BioMed research international · 2024Review
- In vitro, in vivo, and in silico analysis of synbiotics as preventive interventions for lipid metabolism in ethanol-induced adipose tissue injury.Lipids in health and disease · 2023Article
- Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology.International journal of molecular sciences · 2022Review
- Cardioprotective Effect ofMolecules (Basel, Switzerland) · 2022Article
- Pharmacological Justification for the Medicinal Use ofMolecules (Basel, Switzerland) · 2021Article
- Article
- Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.BMC complementary medicine and therapies · 2021Article
- A Network Pharmacology Approach for Exploring the Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- A Comparative Analysis on the Structure and Function of theFrontiers in microbiology · 2021Article
- Saponins as Modulators of the Blood Coagulation System and Perspectives Regarding Their Use in the Prevention of Venous Thromboembolic Incidents.Molecules (Basel, Switzerland) · 2020Review
- LC/MS Analysis of Saponin Fraction from the Leaves ofMolecules (Basel, Switzerland) · 2020Article
- Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition.World journal of gastroenterology · 2020Article
- Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking.Chinese medicine · 2020Article
- Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches.Evidence-based complementary and alternative medicine : eCAM · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary heart disease (CHD) is the worldwide leading cause for cardiovascular death. Panax notoginseng saponin (PNS), which is the main bioactive compound of panax notoginseng, has been generally accepted to exert a remarkable effect on CHD for a long time. However, to reveal the underlying treatment target and corresponding mechanism of PNS against CHD is still a substantial challenge. In this work, the targets and mechanism of PNS against CHD were successfully achieved by pharmacology-based prediction and experimental verification. 36 common targets were screened out through integrating the gene expression profile of CHD and the chemical-protein data of PNS. Then, two key nodes were further selected for verification by experiment after analyzing GO function, KEGG pathway, coexpression, and topology analysis. Results showed that PNS has protected the human umbilical vein endothelial cells from H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.