ArticleFrontiers in immunology2019
Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Pesticides, Rheumatic Diseases, and Emerging Environmental Threats: A Scoping Review of Epidemiologic and Mechanistic Evidence.Rheumatic diseases clinics of North America · 2026Article
- Discovery of Blood-Based Proteins That Mark Benzo[a]pyrene Modulation of Autoimmunity.International journal of molecular sciences · 2025Article
- Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease.Lupus science & medicine · 2025Article
- Exposure to pesticides in Chile and its relationship with carcinogenic potential: a review.Frontiers in public health · 2025Review
- Association between antinuclear antibodies status and preterm birth in Japanese pregnant women: a prospective cohort study from Adjunct Study of the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2024Article
- Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study.Scientific reports · 2024Article
- Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence.Current environmental health reports · 2024Review
- Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.Environmental research · 2024Article
- Association between early life exposure to agriculture, biodiversity, and green space and risk of inflammatory bowel disease: a population-based cohort study.EClinicalMedicine · 2024Article
- Antinuclear Antibodies Are Associated with an Increased Risk of Diffuse Large B-Cell Lymphoma.Cancers · 2023Article
- Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants' Cellular Effects.Molecules (Basel, Switzerland) · 2023Review
- Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease.World journal of gastroenterology · 2023Article
- Impact of occupational pesticide exposure on the human gut microbiome.Frontiers in microbiology · 2023Article
- Levels of anti-cyclic citrullinated peptide and antinuclear antibodies in Brazilian agricultural workers exposed to pesticides and fertilizers.The Science of the total environment · 2022Article
- Pesticide use and risk of systemic autoimmune diseases in the Agricultural Health Study.Environmental research · 2022Article
- Exposure to pesticides and oxidative stress in Brazilian agricultural communities.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2021Article
- Commentary: Novel strategies and new tools to curtail the health effects of pesticides.Environmental health : a global access science source · 2021Article
- Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators.Environmental health perspectives · 2021Article
- Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Farming and pesticide use have been associated with systemic autoimmune diseases, and while certain organochlorine insecticides and other pesticides are suspected to influence risk, the role of specific pesticides in the development of systemic autoimmunity is not known. We measured serum antinuclear autoantibodies (ANA) by immunofluorescence on Hep-2 cells in 668 male farmers in the study of Biomarkers of Exposure and Effect in Agriculture (BEEA; 2010-2013), an Agricultural Health Study (AHS) subcohort. We examined ANA in relation to lifetime use of 46 pesticides first reported at AHS enrollment (1993-1997) and updated at intervals through BEEA enrollment. Odds ratios (OR) and 95% confidence intervals (CI) were estimated after adjusting for age, state, education, season of blood draw, current pesticide use, and correlated pesticides. Having ANA antibodies (3 or 4+ intensity at a 1:80 dilution, 21% of study participants) was associated with a reported history of seeking medical care due to exposure to pesticides (OR 2.15; 95%CI 1.17, 3.95), use of the fumigant methyl bromide (OR 3.16; 95%CI 1.05, 9.5), and use of petroleum oil/distillates (OR 1.50; 95%CI 1.00, 2.25). Using a higher threshold (3 or 4+ at a 1:160 dilution, 9%) ANA positivity was associated with the carbamate insecticide aldicarb (OR 4.82; 95%CI 1.33, 17.5) and greater combined use of four cyclodiene organochlorine insecticides (top tertile of intensity-weighted lifetime days vs. no use; OR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.