Evidence map›Paper›PMID 31354522›Full record

ArticleFrontiers in physiology2019

Circulating Irisin and Myostatin as Markers of Muscle Strength and Physical Condition in Elderly Subjects.

Cristina Planella-Farrugia, Ferran Comas, Mònica Sabater-Masdeu, María Moreno, José María Moreno-Navarrete, Oscar Rovira, Wifredo Ricart, José Manuel Fernández-Real

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Review
  10. Article
  11. The Role of Myokines in Liver Diseases.International journal of molecular sciences · 2025
    Review
  12. Review
  13. Skeletal Muscle as Endocrine Organ.Advances in experimental medicine and biology · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cristina Planella-FarrugiaDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
Ferran ComasDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
Mònica Sabater-MasdeuDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
María MorenoDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
José María Moreno-NavarreteDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
Oscar RoviraDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
Wifredo RicartDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
José Manuel Fernández-RealDepartment of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IdIBGi), CIBEROBN (CB06/03/010) and Carlos III Health Institute (ISCIII), Girona, Spain.
Institut d'Investigació Biomèdica de Girona · ESInstituto de Salud Carlos III · ESUniversity of Girona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveAging is a physiological process known to produce changes in body composition, affecting the musculature and leading to decreased muscle strength. Muscle in response to exercise acts as an endocrine organ, producing and releasing myokines such as irisin and myostatin that modulate muscular growth. Here, we aimed to evaluate the effects of low intensity resistance exercise, with or without protein supplementation, on body composition, anthropometric parameters and circulating irisin and myostatin in elderly subjects.

methodsThis is a prospective and controlled clinical trial in which subjects were randomized into 3 groups: (1) control group (

resultsAt follow-up, RENS resulted in a significant increase in fat free mass (47.4 ± 7.4 vs. 46.5 ± 7.4,

conclusionCirculating irisin, but not myostatin, constitutes a marker for improved muscular performance in elderly subjects.

Indexed as

elderlyexerciseirisinmyokinesprotein supplementation

Identifiers

PMID31354522
PMCPMC6637304
OpenAlexW2949834687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.