ArticleFrontiers in physiology2019
Coupling Between Leg Muscle Activation and EEG During Normal Walking, Intentional Stops, and Freezing of Gait in Parkinson's Disease.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Multimodal Electrophysiological Signals for Machine Learning-Aided Parkinson's Disease Diagnosis.Biosensors · 2026Article
- Electrophysiological Approaches to Understanding Brain-Muscle Interactions During Gait: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Stuttering: the nature of the speech disruptions-a multimodal study of articulation and phonation.Frontiers in human neuroscience · 2025Article
- Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson's disease.Frontiers in neurology · 2023Review
- Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders.Frontiers in network physiology · 2023Article
- Supplementary Motor Area Activity Differs in Parkinson's Disease with and without Freezing of Gait.Parkinson's disease · 2023Article
- A Multi-Modal Analysis of the Freezing of Gait Phenomenon in Parkinson's Disease.Sensors (Basel, Switzerland) · 2022Article
- Synchronized Intracranial Electrical Activity and Gait Recording in Parkinson's Disease Patients With Freezing of Gait.Frontiers in neuroscience · 2022Article
- Review-Emerging Portable Technologies for Gait Analysis in Neurological Disorders.Frontiers in human neuroscience · 2022Review
- Connectivity of EEG synchronization networks increases for Parkinson's disease patients with freezing of gait.Communications biology · 2021Article
- Complexity-Based Analysis of the Variations of Brain and Muscle Reactions in Walking and Standing Balance While Receiving Different Perturbations.Frontiers in human neuroscience · 2021Article
- The Role of Xenobiotics and Trace Metals in Parkinson's Disease.Molecular neurobiology · 2020Review
- Brain Network Oscillations During Gait in Parkinson's Disease.Frontiers in human neuroscience · 2020Review
- Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review.Frontiers in neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we apply novel techniques for characterizing leg muscle activation patterns via electromyograms (EMGs) and for relating them to changes in electroencephalogram (EEG) activity during gait experiments. Specifically, we investigate changes of leg-muscle EMG amplitudes and EMG frequencies during walking, intentional stops, and unintended freezing-of-gait (FOG) episodes. FOG is a frequent paroxysmal gait disturbance occurring in many patients suffering from Parkinson's disease (PD). We find that EMG amplitudes and frequencies do not change significantly during FOG episodes with respect to walking, while drastic changes occur during intentional stops. Phase synchronization between EMG signals is most pronounced during walking in controls and reduced in PD patients. By analyzing cross-correlations between changes in EMG patterns and brain-wave amplitudes (from EEGs), we find an increase in EEG-EMG coupling at the beginning of stop and FOG episodes. Our results may help to better understand the enigmatic pathophysiology of FOG, to differentiate between FOG events and other gait disturbances, and ultimately to improve diagnostic procedures for patients suffering from PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.