Evidence map›Paper›PMID 31354474›Full record

ArticleFrontiers in pharmacology2019

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells.

Marlene C Gerner, Laura Niederstaetter, Liesa Ziegler, Andrea Bileck, Astrid Slany, Lukas Janker, Ralf L J Schmidt, Christopher Gerner, Giorgia Del Favero, Klaus G Schmetterer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Antiviral CD4Communications medicine · 2026
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  13. The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Marlene C GernerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Laura NiederstaetterDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Liesa ZieglerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Andrea BileckDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Astrid SlanyDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Lukas JankerDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Ralf L J SchmidtDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Christopher GernerDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Giorgia Del FaveroDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Klaus G SchmettererDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
University of Vienna · ATMedical University of Vienna · AT

Funding

Austrian Science Fund FWF P 29654
6 · The paper itself

Abstract

While genetic traits and epigenetic modifications mainly encode cell type-specific effector functions, the eventual outcome is also prone to modulation by post-transcriptional regulation mechanisms. T cells are a powerful model for the investigation of such modulatory effects, as common precursor cells may differentiate either to helper CD4

Indexed as

CD4+ T cellsCD8+ T cellsmetabolismmitochondriaprimary human lymphocytesproteome profilereactive oxygen speciesT cell activation

Identifiers

PMID31354474
PMCPMC6635586
OpenAlexW2959600764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.