ArticleFrontiers in behavioral neuroscience2019
Dissociable Neural Responses to Monetary and Social Gain and Loss in Women With Major Depressive Disorder.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- MDMA enhances positive affective responses to social feedback.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.Biological psychology · 2026Article
- Dopaminergic modulation of social reward anticipation in depression: neural effects of amisulpride versus placebo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Striatal Social Reward Sensitivity Predicts Trust-Related Brain Responses Depending on Closeness and Depression.bioRxiv : the preprint server for biology · 2026Article
- Distinct effects of monetary versus social reward magnitudes on the emotional congruency effect in subclinical depression: a word-face Stroop study.Frontiers in psychology · 2026Article
- Reactivity to Interpersonal Conflict: A Correlate of Non-Remission in Childhood Depression-Evidence Across Modalities and Time Scales.Depression and anxiety · 2026Article
- Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach.BMC psychiatry · 2025Article
- Repetition suppression between monetary loss and social pain.BMC psychology · 2024Article
- Corticostriatal responses to social reward are linked to trait reward sensitivity and subclinical substance use in young adults.Social cognitive and affective neuroscience · 2024Article
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Corticostriatal Responses to Social Reward are Linked to Trait Reward Sensitivity and Subclinical Substance Use in Young Adults.bioRxiv : the preprint server for biology · 2024Article
- Uncovering the Neural Correlates of Anhedonia Subtypes in Major Depressive Disorder: Implications for Intervention Strategies.Biomedicines · 2023Article
- Sensitivity to intrinsic rewards is domain general and related to mental health.Nature. Mental health · 2023Article
- Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.Brain : a journal of neurology · 2022Article
- Functional activation of insula and dorsal anterior cingulate for conflict control against larger monetary loss in young adults with subthreshold depression: a preliminary study.Scientific reports · 2022Article
- Substance Abuse in Emerging Adults: The Role of Neuromelanin and Ventral Striatal Response to Social and Monetary Rewards.Brain sciences · 2022Article
- Neural response to monetary and social feedback demonstrates differential associations with depression and social anxiety.Social cognitive and affective neuroscience · 2021Article
- Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.Bipolar disorders · 2021Article
- "Next up for psychiatry: rejection sensitivity and the social brain".Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Neuroimaging studies have revealed aberrant reward and loss processing in patients with major depressive disorder (MDD). While most studies use monetary stimuli to study these processes, it is important to consider social stimuli given that the social environment plays a significant role in the development and maintenance of MDD. In the present study, we examined whether monetary gain/loss and social acceptance/rejection would elicit dissociable salience-related neural responses in women diagnosed with MDD compared to healthy control (HC) women. Twenty women diagnosed with MDD and 20 matched HC women performed the monetary incentive delay task (MID) and the social feedback task (SFT) during functional magnetic resonance imaging (fMRI). This study focused on women since women have a higher rate of MDD, higher frequency of relapse, and are more likely to develop MDD as a consequence of negative interpersonal relationships compared to men. We found that during the MID, HCs but not MDD patients demonstrated strong overlapping activations in the right anterior insula (AI) in response to both monetary gain and loss. During the SFT, MDD patients but not HCs showed overlapping activations in the AI in response to social acceptance and rejection. Our results may suggest a dissociation such that MDD patients show decreased sensitivity to monetary stimuli whether gain or loss, and increased sensitivity to social stimuli whether acceptance or rejection, although this will need to be verified in larger samples with direct comparisons between groups and stimuli. These data demonstrate distinct abnormalities in reward and loss processing that converge within the AI. Our findings also highlight the critical need to assess across both non-social and social domains when examining reward and loss systems in MDD to broaden our understanding of the disorder and identify novel targets for treatment.
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