Evidence map›Paper›PMID 31354394›Full record

ReviewContrast media & molecular imaging2019

Combining Diagnostic Imaging and Pathology for Improving Diagnosis and Prognosis of Cancer.

Orazio Schillaci, Manuel Scimeca, Nicola Toschi, Rita Bonfiglio, Nicoletta Urbano, Elena Bonanno

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05575765 (Clinical Validation of Multimodal Digestive Endoscopy in the Diagnosis of Colorectal Lesions), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05575765 suspendednot on this mapstarted 2022, after this paper: background citation

Clinical Validation of Multimodal Digestive Endoscopy in the Diagnosis of Colorectal Lesions

TypeobservationalSponsorXijing Hospital of Digestive DiseasesRan2022 to 2025Enrolled20ConditionsColorectal Neoplasms, Confocal Laser Endomicroscopy, Endoscopy, Digestive System, Molecular Imaging
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. [Molecular and cellular biochemistry · 2022
    Article
  10. Article
  11. Harnessing non-destructive 3D pathology.Nature biomedical engineering · 2021
    Review
  12. Review
  13. Article
  14. Radiolabeled PET/MRI Nanoparticles for Tumor Imaging.Journal of clinical medicine · 2019
    Review
  15. Journal of clinical medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Orazio SchillaciDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.
Manuel ScimecaDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.ORCID 0000-0003-0585-1309
Nicola ToschiDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.ORCID 0000-0003-1929-5833
Rita BonfiglioDepartment of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.ORCID 0000-0003-4172-2977
Nicoletta UrbanoNuclear Medicine, Policlinico "Tor Vergata", Rome, Italy.
Elena BonannoDepartment of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome 00133, Italy.ORCID 0000-0002-0222-0141
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the era of personalized medicine, the management of oncological patients requires a translational and multidisciplinary approach. During early phases of cancer development, biochemical alterations of cell metabolism occur much before the formation of detectable tumour masses. Current molecular imaging techniques, targeted to the study of molecular kinetics, employ molecular tracers capable of detecting cancer lesions with both high sensitivity and specificity while also providing essential information for both prognosis and therapy. On the contrary, complementary and crucial information is provided by histopathological examination and ancillary techniques such as immunohistochemistry. Thus, the successful collaboration between diagnostic imaging and anatomic pathology can represent a fundamental step in the "tortuous" but decisive path towards personalized medicine.

Indexed as

PrognosisHumansMolecular ImagingNeoplasmsPrecision MedicineTechnetiumTomography, Emission-Computed, Single-PhotonTechnetium

Identifiers

PMID31354394
PMCPMC6636452
OpenAlexW2955341851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.