Evidence map›Paper›PMID 31354385›Full record

ArticleMediators of inflammation2019

MicroRNA-30-3p Suppresses Inflammatory Factor-Induced Endothelial Cell Injury by Targeting TCF21.

Zhenyu Zhou, Yu Chen, Dongying Zhang, Shiyong Wu, Tao Liu, Guoqiang Cai, Shu Qin

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
  6. Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Review
  7. Emerging Role of MicroRNA-30c in Neurological Disorders.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Unveiling ncRNA regulatory axes in atherosclerosis progression.Clinical and translational medicine · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhenyu ZhouDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yu ChenComprehensive Ward, Nanchong Central Hospital, The Second Clinical School of North Sichuan Medical College, Nanchong, China.
Dongying ZhangDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Shiyong WuDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Tao LiuDepartment of Cardiology, Nanchong Central Hospital, The Second Clinical School of North Sichuan Medical College, Nanchong, China.ORCID https://orcid.org/0000-0002-4740-5465
Guoqiang CaiDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Shu QinDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID https://orcid.org/0000-0002-9986-1630
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNNorth Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is one of the leading causes of mortality worldwide. Growing evidence suggested that miRNAs contributed to the progression of atherosclerosis. miR-30-5p was found involved in various diseases. However, the role of miR-30-5p in regulation of atherosclerosis is not known. Here, we aim to investigate the effects of miR-30-5p on regulating the progression of atherosclerosis. The expression levels of miR-30-5p in serum collected from atherosclerosis patients and normal healthy people were analyzed by qRT-PCR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway bioinformatics were carried out to reveal the possible signaling pathways involved in the mode of action of miR-30-5p. A potential target gene of miRNA-30-5p was searched and examined by a luciferase reporter assay. ELISA, Western blot, proliferation, and flow cytometry assays were performed to assess the biological functional role of miR-30-5p

Indexed as

ApoptosisAtherosclerosisBasic Helix-Loop-Helix ProteinsBlotting, WesternCell ProliferationEndothelial CellsFlow CytometryHealthy VolunteersHumansHuman Umbilical Vein Endothelial CellsL-Lactate DehydrogenaseMicroRNAsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionTumor Necrosis Factor-alphaBasic Helix-Loop-Helix ProteinsL-Lactate DehydrogenaseMicroRNAsMIRN30b microRNA, humanReactive Oxygen SpeciesTCF21 protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID31354385
PMCPMC6636441
OpenAlexW2954849440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.