ArticleInternational journal of nanomedicine2019
Comparative study of in vitro effects of different nanoparticles at non-cytotoxic concentration on the adherens junction of human vascular endothelial cells.
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Mesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway.Drug delivery · 2023Article
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- Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles.Beilstein journal of nanotechnology · 2023Review
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- Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells.Antioxidants (Basel, Switzerland) · 2022Article
- Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages.Particle and fibre toxicology · 2021Article
- Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity.Bioactive materials · 2021Review
- Gold Nanoparticles Functionalized with Angiogenin for Wound Care Application.Nanomaterials (Basel, Switzerland) · 2021Article
- Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect.Advances in experimental medicine and biology · 2021Article
- The Interactions of Quantum Dot-Labeled Silk Fibroin Micro/Nanoparticles with Cells.Materials (Basel, Switzerland) · 2020Article
- Nitroxide-Modified Protein-Incorporated Nanoflowers with Dual Enzyme-Like Activities.International journal of nanomedicine · 2020Article
- BiogenicToxicology research · 2019Article
- Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction.Toxicology research · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffects of different nanoparticles (NPs) exposure at acutely non-cytotoxic concentrations are particularly worthy to figure out, compare, and elucidate.
objectiveTo investigate and compare the effect of a small library of NPs at non-cytotoxic concentration on the adherens junction of human umbilical vein endothelial cells (HUVECs), obtaining new insights of NPs safety evaluation. MATERIALS AND
methodsThe HUVECs layer was exposed to NPs including gold (Au), platinum (Pt), silica (SiO
resultsThe acutely non-cytotoxic concentrations of different NPs were determined and applied to HUVECs. The NPs increased the level of intracellular ROS and the activity of CAT to different degrees, depending on the characteristics. At the same time, the HUVECs lost their adherens junction protein VE-cadherin and gaps were formed between the cells. The NP-induced oxidative stress and gap formation could be rescued by the supplementary N-acetylcysteine in the incubation.
conclusionThe increase of intracellular ROS and CAT activity was one common effect of NPs, even at the non-cytotoxic concentration, and the degree was dependent on the composition, surface chemistry, and size distribution of the NP. The effect led to the gap formation between the cells, while could be rescued by the antioxidant. Therefore, the variation of adherens junction between endothelial cells was suggested to evaluate for NPs when used as therapeutics and diagnostics.
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