ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2019
Cancer IgG, a potential prognostic marker, promotes colorectal cancer progression.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- The tumor-suppressive function of the unique H domain of FCGBP and its potential as a therapeutic target in colorectal cancer.BMC cancer · 2026Article
- Dynamic monitoring of immunoglobulin G as a prognostic indicator after curative resection in high-risk stage II-III colorectal cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
- Tumor markers and multimodal magnetic resonance imaging in predicting rectal cancer stage and differentiation.World journal of gastrointestinal oncology · 2025Article
- Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis.Neoplasia (New York, N.Y.) · 2025Article
- Unraveling the dual roles of tumor-infiltrating antibodies in solid tumors: friend or foe in the tumor microenvironment?Frontiers in immunology · 2025Review
- The Expression of Non B Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Non B Cell-Derived Immunoglobulins in Intestinal Tract.Advances in experimental medicine and biology · 2024Review
- Functional analysis of tumor-derived immunoglobulin lambda and its interacting proteins in cervical cancer.BMC cancer · 2023Article
- Clinical value of circulating tumor cells and hematological parameters in 617 Chinese patients with colorectal cancer: retrospective analysis.BMC cancer · 2023Article
- Nutritional and immune-related indicators-based Nomogram for predicting overall survival of surgical oral tongue squamous cell carcinoma.Scientific reports · 2023Article
- Autoantibodies - enemies, and/or potential allies?Frontiers in immunology · 2022Review
- Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development.International journal of molecular sciences · 2021Review
- Current insights into the expression and functions of tumor-derived immunoglobulins.Cell death discovery · 2021Review
- The neglected brothers come of age: B cells and cancer.Seminars in immunology · 2021Review
- Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.Frontiers in immunology · 2021Review
- High Expression of Cancer-IgG Is Associated With Poor Prognosis and RadioresistanceFrontiers in oncology · 2021Article
- Upregulated Expression of Cancer-Derived Immunoglobulin G Is Associated With Progression in Glioma.Frontiers in oncology · 2021Article
- Commentary: High Expression of Cancer-IgG Is Associated With Poor Prognosis and RadioresistanceFrontiers in oncology · 2021Article
- Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis.Open life sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCurrently, no satisfactory targets for colorectal cancer or markers for immunotherapy and diagnosis and prognosis are available. Immunoglobulin G (IgG) is widely expressed in many cancers, and it promotes cancer progression. This study explored the role of cancer-derived IgG (CIgG) in colorectal cancer.
methodsFirst, using a monoclonal antibody to CIgG, we examined the expression levels of CIgG in colorectal cancer cell lines by western blot and immunofluorescence analyses and in tissue specimens by immunohistochemistry. Second, the variable region gene was amplified by nested polymerase chain reaction (PCR), and PCR products were sequenced and analyzed. Third, we investigated the effect of CIgG on colorectal cancer cells by cell proliferation, wound healing, migration and invasion assays, and colony formation assay. Fourth, we performed
resultsWe found that CIgG is widely expressed in colorectal cancer cells, and the overexpression of CIgG indicates significantly poor colorectal cancer prognosis. Furthermore, CIgG knockdown significantly inhibits the proliferation, migration and invasion ability of cells, and tumor growth
conclusionsCIgG is a potential human oncogene in colorectal cancer and that it has potential for application as a novel target in targeted therapy and a marker for prognostic evaluation.
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