Evidence map›Paper›PMID 31354089›Full record

Trial reportVascular medicine (London, England)2019

Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial.

Ido Weinberg, Suresh Vedantham, Amber Salter, Gail Hadley, Noor Al-Hammadi, Clive Kearon, Jim A Julian, Mahmood K Razavi, Heather L Gornik, Samuel Z Goldhaber and 9 more

Open access · bronzeAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Vascular medicine (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Angioplasty or stenting for deep venous thrombosis.The Cochrane database of systematic reviews · 2025
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  11. Prevention of the Postthrombotic Syndrome: Where Do We Stand?Seminars in interventional radiology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 2 countries.

Ido WeinbergVascular Medicine Section, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-4633-5132
Suresh VedanthamMallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, USA.
Amber SalterDivision of Biostatistics, Washington University in St Louis, St Louis, MO, USA.
Gail HadleyVascular Ultrasound Core-Laboratory (VasCore), Boston, MA, USA.
Noor Al-HammadiDivision of Biostatistics, Washington University in St Louis, St Louis, MO, USA.
Clive KearonDepartment of Oncology, McMaster University, Hamilton, ON, Canada.
Jim A JulianDepartment of Oncology, McMaster University, Hamilton, ON, Canada.
Mahmood K RazaviSt Joseph's Hospital, Orange, CA, USA.
Heather L GornikVascular Center, University Hospitals Harrington Heart & Vascular Institute, Cleveland, OH, USA.ORCID 0000-0002-5849-4010
Samuel Z GoldhaberDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Anthony J ComerotaInova Heart and Vascular Institute, Inova Alexandria Hospital, Alexandria, VA, USA.
Andrei L KindzelskiDivision of Blood Diseases & Resources, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Robert M SchainfeldVascular Medicine Section, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
John F AngleDepartment of Radiology, University of Virginia, Charlottesville, VA, USA.
Sanjay MisraDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5662-796X
Jonathan A SchorStaten Island University Hospital, New York, NY, USA.
Darren HurstDepartment of Radiology, St Elizabeth Healthcare, Edgewood, KY, USA.
Michael R JaffHarvard Medical School, Boston, MA, USA.
ATTRACT Trial Investigators
Washington University in St. Louis · USMassachusetts General Hospital · USBrigham and Women's Hospital · USHarvard University · USInova Alexandria Hospital · USJuravinski Hospital · CAMayo Clinic in Arizona · USMcMaster University · CANational Institutes of Health · USStaten Island University Hospital · USSt. Elizabeth Healthcare · USSt. Joseph's Hospital · USUniversity Hospitals Cleveland Medical Center · USUniversity of Virginia · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
The Role of Hypoxia In Venous Neointimal Hyperplasia In Hemodialysis GraftsR01HL098967 · NHLBI · MAYO CLINIC ROCHESTER · PI Sanjay Misra · 2010 to 2026
$10.4M
Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8M
PHARMACOMECHANICAL CATHETER-DIRECTED THROMBOLYSIS FOR ACUTE DVT - ATTRACT TRIALU01HL088476 · NHLBI · WASHINGTON UNIVERSITY · PI VEDANTHAM, SURESH · 2008 to 2013
$7.2M
Data Coordinating Centre for ATTRACT TrialU01HL088118 · NHLBI · MCMASTER UNIVERSITY · PI KEARON, CLIVE · 2008 to 2012
$2.9M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL098967NHLBI NIH HHS U01 HL088118NHLBI NIH HHS U01 HL088476NHLBI NIH HHS U54 HL112303
6 · The paper itself

Abstract

Few studies have documented relationships between endovascular therapy, duplex ultrasonography (DUS), post-thrombotic syndrome (PTS), and quality of life (QOL). The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial randomized 692 patients with acute proximal deep vein thrombosis (DVT) to receive anticoagulation or anticoagulation plus pharmacomechanical catheter-directed thrombolysis (PCDT). Compression DUS was obtained at baseline, 1 month and 12 months. Reflux DUS was obtained at 12 months in a subset of 126 patients. Clinical outcomes were collected over 24 months. At 1 month, patients who received PCDT had less residual thrombus compared to Control patients, evidenced by non-compressible common femoral vein (CFV) (21% vs 35%,

Indexed as

Catheterization, PeripheralThrombolytic TherapyUltrasonography, Doppler, DuplexAdministration, IntravenousAdultFemaleFibrinolytic AgentsHumansMaleMiddle AgedNorth AmericaPostthrombotic SyndromePredictive Value of TestsQuality of LifeRisk FactorsSeverity of Illness IndexFibrinolytic Agentsdeep vein thrombosis (DVT)post-thrombotic syndromethrombolytic therapyultrasound

Identifiers

PMID31354089
PMCPMC6943930
OpenAlexW2965579018

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.