Evidence map›Paper›PMID 31353894›Full record

ArticleJournal of the American Chemical Society2019

Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles.

Wei Chen, Chi-An Cheng, Emily D Cosco, Shyam Ramakrishnan, Jakob G P Lingg, Oliver T Bruns, Jeffrey I Zink, Ellen M Sletten

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
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  16. Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emily D CoscoHelmholtz Pioneer Campus, Helmholtz Zentrum München , D-85764 Neuherberg , Germany.
Shyam RamakrishnanHelmholtz Pioneer Campus, Helmholtz Zentrum München , D-85764 Neuherberg , Germany.
Jakob G P LinggHelmholtz Pioneer Campus, Helmholtz Zentrum München , D-85764 Neuherberg , Germany.
Oliver T BrunsHelmholtz Pioneer Campus, Helmholtz Zentrum München , D-85764 Neuherberg , Germany.

Funding

Biocompatible fluorophores for shortwave infrared imagingR01EB027172 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Ellen May Sletten · 2019 to 2026
$2.9M
NIBIB NIH HHS R01 EB027172
6 · The paper itself

Abstract

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging

Indexed as

AnimalsBenzothiazolesContrast MediaDrug StabilityInfrared RaysMice, NudeNanoparticlesOptical ImagingPolyethylene GlycolsSilicon DioxideBenzothiazolesContrast MediaPolyethylene GlycolsSilicon Dioxide

Identifiers

PMID31353894
PMCPMC6746239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.