Evidence map›Paper›PMID 31353865›Full record

ArticleAnnals of clinical and translational neurology2019

Neuroinflammation in frontotemporal lobar degeneration revealed by

Min-Jeong Kim, Meghan McGwier, Kimberly J Jenko, Joseph Snow, Cheryl Morse, Sami S Zoghbi, Victor W Pike, Robert B Innis, William C Kreisl

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.medRxiv : the preprint server for health sciences · 2024
    Article
  6. Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
  8. Article
  9. Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  10. Have (R)-[European journal of nuclear medicine and molecular imaging · 2021
    Article
  11. Uses of Human MR and PET Imaging in Research of Neurodegenerative Brain Diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Min-Jeong KimMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.ORCID 0000-0002-0998-5972
Meghan McGwierMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
Kimberly J JenkoMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
Joseph SnowOffice of the Clinical Director, National Institute of Mental Health, Bethesda, Maryland.
Cheryl MorseMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland.
William C KreislTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York.
National Institute of Mental Health · USColumbia University · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NIMH NIH HHS ZIA MH002793NIMH NIH HHS ZIA MH002795
6 · The paper itself

Abstract

This study used

Indexed as

AdultAgedCarbon RadioisotopesFemaleFluorodeoxyglucose F18Frontotemporal Lobar DegenerationHumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABACarbon-11Carbon RadioisotopesFluorodeoxyglucose F18RadiopharmaceuticalsReceptors, GABATSPO protein, human

Identifiers

PMID31353865
PMCPMC6649481
OpenAlexW2952450428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.