GuidelineJournal of thrombosis and haemostasis : JTH2019
The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH.
Registry-linked trialOpen access · bronzeAbstract readPractice GuidelineReview
In one paragraph
Guideline in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04309240 (The Efficacy and Safety of Rivaroxaban for Thromboprophylaxis in High-risk Cancer Patients With Totally Implantable Access Ports), which is not on this map. Cited by 70 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
17.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy and Safety of Rivaroxaban for Thromboprophylaxis in High-risk Cancer Patients With Totally Implantable Access Ports: a Prospective Randomized Controlled Trial
Who cites it
70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Anticoagulation for the prevention of arterial thromboembolism in cancer patients by primary tumour site: a systematic review and meta-analysis of randomized trials.European heart journal. Cardiovascular pharmacotherapy · 2025Pooled it
- The Role of Anticoagulation on Venous Thromboembolism Primary Prophylaxis in Low- to Intermediate-Risk Ambulatory Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- Mitigating the risk of venous thromboembolism in patients with multiple myeloma receiving immunomodulatory-based therapy.Hematology. American Society of Hematology. Education Program · 2022Pooled it
- Primary thromboprophylaxis in ambulatory cancer patients with a high Khorana score: a systematic review and meta-analysis.Blood advances · 2020Pooled it
- Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia.The Cochrane database of systematic reviews · 2020Pooled it
- D-Dimer Enhances Risk-Targeted Thromboprophylaxis in Ambulatory Patients with Cancer.The oncologist · 2020Trial
- Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.Circulation. Genomic and precision medicine · 2026Article
- Gaps Between Guidelines and Practice in VTE Prevention for Advanced NSCLC Outpatients: A Nationwide Cross-Sectional Study in China.Healthcare (Basel, Switzerland) · 2026Article
- Unmet Needs and Challenges in Cancer-Associated Venous Thromboembolism.International journal of molecular sciences · 2026Review
- Case Report: Upper extremity deep vein thrombosis revealing an occult invasive ductal breast carcinoma.Frontiers in cardiovascular medicine · 2026Article
- Risk management in the dual crisis of unresectable colorectal cancer and deep vein thrombosis: navigating between hemorrhage and antithrombosis.Frontiers in oncology · 2026Article
- Development and validation of the CHI-CAT score: a novel tool for assessing cancer-associated venous thromboembolism risk in China.BMC cancer · 2025Article
- Implementation failure: thromboprophylaxis in ambulatory patients with cancer.Hematology. American Society of Hematology. Education Program · 2025Review
- Best evidence summary on anticoagulant management in patients with cancer-associated venous thromboembolism.Asia-Pacific journal of oncology nursing · 2025Review
- Cancer-Associated Thrombosis: Surveying Patients' Awareness and Education Needs.JCO oncology advances · 2025Article
- Near-fatal saddle pulmonary embolism following chemoradiotherapy and brachytherapy for locally advanced cervical cancer: A case series.Journal of contemporary brachytherapy · 2025Article
- Venous Thromboembolism in Patients with Glioblastoma: Molecular Mechanisms and Clinical Implications.Thrombosis and haemostasis · 2025Review
- Current practices and challenges in the management of cancer-associated thrombosis: a survey of Italian oncologists.Frontiers in oncology · 2025Article
- Indications and outcomes of rivaroxaban use in cats.Frontiers in veterinary science · 2025Article
- Pharmacodynamics of Rivaroxaban and Dabigatran in Adults with Diffuse Large B-Cell Lymphoma Receiving R-CHOP Immunochemotherapy.Pharmaceutics · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors at 10 institutions in 8 countries.
Tzu-Fei WangDivision of Hematology, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0003-2407-9000
Jeffrey I ZwickerDivision of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5810-6893
Cihan AyClinical Division of Haematology and Haemostaseology, Department of Medicine, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2607-9717
Ingrid PabingerClinical Division of Haematology and Haemostaseology, Department of Medicine, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Anna FalangaDepartment of Medicine and Surgery, University of Milan Bicocca, Milan, Italy.
Darko AnticClinic for Hematology, Clinical Center Serbia, University of Belgrade, Belgrade, Serbia.
Simon NobleMarie Curie Palliative Care Research Centre, Cardiff University, Cardiff, Wales, UK.
Alok A KhoranaTaussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Marc CarrierDepartment of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON, Canada.
Guy MeyerDepartment of Respiratory Disease, Hopital Europeen Georges Pompidou, AP-HP, INSERM CIC1418, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Beth Israel Deaconess Medical Center · USCleveland Clinic · USComprehensive Cancer Center Vienna · ATDélégation Paris 5 · FRMarie Curie · GBOspedale Papa Giovanni XXIII · ITSechenov University · RUThe Ohio State University Wexner Medical Center · USUniversity of Belgrade · RSUniversity of Ottawa · CA
Funding
Novel approaches to improve prediction of cancer-associated thrombosisU01HL143402 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KHORANA, ALOK A, MCCRAE, KEITH R. · 2018 to 2022
$4.7MBiomarkers and mechanisms in cancer associated thrombosisU01HL143365 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, FLAUMENHAFT, ROBERT C · 2018 to 2022
$4.3MMarie Curie MCCC-FCO-17-CANHLBI NIH HHS U01 HL143365NHLBI NIH HHS U01 HL143402
Abstract
PubMed holds no abstract for this paper.
Indexed as
Administration, OralEvidence-Based MedicineFactor Xa InhibitorsHumansNeoplasmsPyrazolesPyridonesRandomized Controlled Trials as TopicRisk FactorsRivaroxabanTreatment OutcomeVenous ThromboembolismapixabanFactor Xa InhibitorsPyrazolesPyridonesRivaroxaban
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT04309240ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.