Evidence map›Paper›PMID 31353371›Full record

ArticleChemical communications (Cambridge, England)2019

Click and photo-release dual-functional nucleic acid nanostructures.

Vibhav A Valsangkar, Arun Richard Chandrasekaran, Lifeng Zhuo, Song Mao, Goh Woon Lee, Megan Kizer, Xing Wang, Ken Halvorsen, Jia Sheng

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Nuclease resistance of DNA nanostructures.Nature reviews. Chemistry · 2021
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Vibhav A ValsangkarThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu and Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA. jsheng@albany.edu.ORCID http://orcid.org/0000-0002-0342-6125
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu.ORCID http://orcid.org/0000-0001-6757-5464
Lifeng ZhuoThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu.
Song MaoThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu and Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA. jsheng@albany.edu.
Goh Woon LeeThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu and Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA. jsheng@albany.edu.
Megan KizerDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID http://orcid.org/0000-0003-3549-8606
Xing WangDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID http://orcid.org/0000-0001-9930-3287
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu.ORCID http://orcid.org/0000-0002-2578-1339
Jia ShengThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu and Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA. jsheng@albany.edu.ORCID http://orcid.org/0000-0001-6198-390X

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
Environmental Epitranscriptomic Studies and Tools Focused on the Wobble UridineR15GM124627 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SHENG, JIA · 2017 to 2017
$443k
NIGMS NIH HHS R15 GM124627NIGMS NIH HHS R35 GM124720
6 · The paper itself

Abstract

We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

Indexed as

AnimalsBacillus PhagesBase SequenceCattleClick ChemistryDNADrug CarriersFluoresceinsFluorescenceFluorescent DyesNanostructuresNucleic Acid ConformationRNAUltraviolet RaysDNADrug CarriersFluoresceinsFluorescent DyesRNA

Identifiers

PMID31353371
PMCPMC6687541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.