ArticleCell2019
Repressive Gene Regulation Synchronizes Development with Cellular Metabolism.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits thebioRxiv : the preprint server for biology · 2026Article
- NADThe EMBO journal · 2026Article
- miRNAs in Amyotrophic Lateral Sclerosis: Tiny Molecules, Tremendous Impact.Molecular neurobiology · 2026Review
- Applicability of Trichoderma spp. in sustainable agriculture against fungal and nematode phytopathogens: a review.Folia microbiologica · 2026Review
- Quantitative modeling of mRNA degradation reveals tempo-dependent mRNA clearance in early embryos.Nucleic acids research · 2025Article
- Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis.Life science alliance · 2024Article
- Metabolic mechanisms of species-specific developmental tempo.Developmental cell · 2024Review
- Rapid adaptation of cellular metabolic rate to the MicroRNA complements of mammals and its relevance to the evolution of endothermy.iScience · 2024Article
- Energy metabolism modulates the regulatory impact of activators on gene expression.Development (Cambridge, England) · 2024Article
- Energy metabolism modulates the regulatory impact of activators on gene expression.bioRxiv : the preprint server for biology · 2023Article
- Implications of miRNAs dysregulation in amyotrophic lateral sclerosis: Challenging for clinical applications.Frontiers in neuroscience · 2023Review
- Mathematical models to study the biology of pathogens and the infectious diseases they cause.iScience · 2022Review
- Nanomedicines Targeting Metabolism in the Tumor Microenvironment.Frontiers in bioengineering and biotechnology · 2022Review
- Article
- A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy.Developmental biology · 2021Article
- MicroRNA-mediated regulation of glucose and lipid metabolism.Nature reviews. Molecular cell biology · 2021Review
- Gene Regulation and Cellular Metabolism: An Essential Partnership.Trends in genetics : TIG · 2021Review
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- Mining Social Media Data for Biomedical Signals and Health-Related Behavior.Annual review of biomedical data science · 2020Article
- Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator.The EMBO journal · 2020Article
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10 authors.
Funding
Abstract
Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein stability are lost, fewer errors in Drosophila development occur when metabolism is lowered. We demonstrate the universality of this phenomenon by eliminating the entire microRNA family of repressors and find that development to maturity can be largely rescued when metabolism is reduced. Using a mathematical model that replicates GRN dynamics, we find that lowering metabolism suppresses the emergence of developmental errors by curtailing the influence of auxiliary repressors on GRN output. We experimentally show that gene expression dynamics are less affected by loss of repressors when metabolism is reduced. Thus, layered repression provides robustness through error suppression and may provide an evolutionary route to a shorter reproductive cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.