Evidence map›Paper›PMID 31352824›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Proximal Tubule-Specific Deletion of the NHE3 (Na

Xiao C Li, Dongmin Zhu, Xu Chen, Xiaowen Zheng, Chunling Zhao, Jianfeng Zhang, Manoocher Soleimani, Isabelle Rubera, Michel Tauc, Xinchun Zhou and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. The relationship between estrogen and renin angiotensin system components in the context of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  6. Article
  7. A key role of ATAmerican journal of physiology. Renal physiology · 2025
    Article
  8. Article
  9. Article
  10. Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  11. Article
  12. Deletion of ATAmerican journal of physiology. Renal physiology · 2024
    Article
  13. Review
  14. Review
  15. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xiao C LiFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Dongmin ZhuFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Xu ChenFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Xiaowen ZhengFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Chunling ZhaoFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Jianfeng ZhangFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
Manoocher SoleimaniDivision of Nephrology and Hypertension, Department of Internal Medicine, The University of Cincinnati College of Medicine, OH (M.S.).
Isabelle RuberaLaboratoire de Physiomédecine Moléculaire, LP2M, UMR-CNRS 7370, Université Côte d'Azur, Nice Cedex 2, France (I.R., M.T.).
Michel TaucLaboratoire de Physiomédecine Moléculaire, LP2M, UMR-CNRS 7370, Université Côte d'Azur, Nice Cedex 2, France (I.R., M.T.).
Xinchun ZhouDepartment of Pathology (X. Zhou), University of Mississippi Medical Center, Jackson.
Jia L ZhuoFrom the Department of Pharmacology and Toxicology (X.C.L., D.Z., X.C., X. Zheng, C.Z., J.Z., J.L.Z.), University of Mississippi Medical Center, Jackson.
University of Mississippi Medical Center · USJackson Memorial Hospital · USGuangxi Medical University · CNUniversity of Cincinnati Medical Center · US

Funding

Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
The Na+/H+ Exchanger 3, Pressure Natriuresis, and HypertensionR56HL130988 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2016 to 2016
$381k
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
The Role of Intercalated Cells and Their Acid Base and Electrolyte Transport Machinery in Kidney Cystogenesis by Tuberous SclerosisI01BX001000 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI SOLEIMANI, MANOOCHER · 2012 to 2025
–
BLRD VA I01 BX001000NHLBI NIH HHS R56 HL130988NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R56 DK067299
6 · The paper itself

Abstract

The present study directly tested the hypothesis that the NHE3 (Na

Indexed as

Angiotensin IIAnimalsDisease Models, AnimalFemaleHypertensionInjections, IntraperitonealKidney Tubules, ProximalLosartanMaleMiceMice, KnockoutRandom AllocationReceptor, Angiotensin, Type 1Reference ValuesSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersAngiotensin IILosartanReceptor, Angiotensin, Type 1Slc9a3 protein, mouseSodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangersangiotensin IIblood pressurehypertensionkidneymice

Identifiers

PMID31352824
PMCPMC6685743
OpenAlexW2964593755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.