ArticleHypertension (Dallas, Tex. : 1979)2019
Maternal Cardiovascular Dysregulation During Early Pregnancy After In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis.Human reproduction update · 2023Pooled it
- Large artery stiffness is elevated in women with a prior pregnancy conceived via in vitro fertilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Pharmacodynamic interaction analysis of dydrogesterone, progesterone, and estradiol in combination-progestin HRT frozen embryo transfer: a prospective clinical cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Monochorionic twin pregnancies conceived through assisted reproduction: Maternal and perinatal clinical outcomes.Acta obstetricia et gynecologica Scandinavica · 2026Observational
- Human placentation: foundations and implications for reproductive endocrinology and infertility.Systems biology in reproductive medicine · 2025Review
- Corpus luteum number and maternal circulatory adaptation from early pregnancy onwards: the Rotterdam Periconception Cohort (Predict Study).Human reproduction (Oxford, England) · 2025Article
- Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum.Journal of assisted reproduction and genetics · 2025Article
- Mid-pregnancy circulating placental growth factor (PlGF) and obstetrical outcomes following nonovulatory and ovulatory frozen embryo transfer cycles.Journal of assisted reproduction and genetics · 2025Article
- Association of hyperuricemia with higher miscarriage rates and lower live birth rates in women undergoing IVF/ICSI.Journal of ovarian research · 2025Article
- Live birth rates are unrelated to sex-steroid levels on ET day in a dydrogesterone-based 'programmed-ovulatory FET' protocol: a multi-centric prospective cohort study.Human reproduction open · 2025Article
- Pregnancy and perinatal outcomes after modified natural cycle-frozen embryo transfers according to size of the dominant follicle on the hCG trigger day.Human reproduction open · 2025Article
- Effect of ART treatments on maternal and neonatal outcomes in singleton live births: A large-scale retrospective cohort study.Heliyon · 2024Article
- Comparison of Fetal Crown-Rump Length Measurements between Thawed and Fresh Embryo Transfer.Journal of clinical medicine · 2024Article
- Pathologic maternal and neonatal outcomes associated with programmed embryo transfer: potential etiologies and strategies for prevention.Journal of assisted reproduction and genetics · 2024Review
- The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester.Human reproduction update · 2023Review
- Is artificial endometrial preparation more associated with early-onset or late-onset preeclampsia after frozen embryo transfer?Journal of assisted reproduction and genetics · 2023Article
- Article
- Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China.BMC pregnancy and childbirth · 2022Article
- The effect of mildly stimulated cycle versus artificial cycle on pregnancy outcomes in overweight/obese women with PCOS prior to frozen embryo transfer: a retrospective cohort study.BMC pregnancy and childbirth · 2022Article
- The impact of endometrial preparation for frozen embryo transfer on maternal and neonatal outcomes: a review.Reproductive biology and endocrinology : RB&E · 2022Review
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
Commonly used in vitro fertilization protocols produce pregnancies without a corpus luteum (CL), a major source of reproductive hormones. In vitro fertilization pregnancies without a CL showed deficient gestational increases of central (aortic) arterial compliance during the first trimester and were at increased risk for developing preeclampsia. Here, we investigated whether there was generalized impairment of cardiovascular adaptation in in vitro fertilization pregnancies without a CL compared with pregnancies conceived spontaneously or through ovarian stimulation, which lead to 1 and >1 CL, respectively (n=19-26 participants per cohort). Prototypical maternal cardiovascular adaptations of gestation were serially evaluated noninvasively, initially during the follicular phase before conception, 6× in pregnancy, and then, on average, 1.6 years post-partum. The expected increases of cardiac output, left atrial dimension, peak left ventricular filling velocity in early diastole (E wave velocity), peripheral/central arterial pulse pressure ratio, and global AC, as well as decrease in augmentation index were significantly attenuated or absent during the first trimester in women who conceived without a CL, when compared with the 1 and >1 CL cohorts, which were comparable. Thereafter, these cardiovascular measures showed recovery in the 0 CL group except for E wave velocity, which remained depressed. These results provided strong support for a critical role of CL factor(s) in the transformation of the maternal cardiovascular system in early gestation. Regimens that lead to the development of a CL or replacement of missing CL factor(s) may be indicated to improve cardiovascular function and reduce preeclampsia risk in in vitro fertilization pregnancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.