ArticleThe American journal of psychiatry2019
White Matter in Schizophrenia Treatment Resistance.
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Article in The American journal of psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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33citing papers in PubMed, 3 pooled it
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain structural abnormalities in treatment-resistant schizophrenia.Molecular psychiatry · 2026Pooled it
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- Suicide attempts, white matter microstructure, and cognitive function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.Molecular psychiatry · 2026Article
- Deviation in development of dorsal association tracts during preadolescence links to concurrent and future cognitive performance and transdiagnostic psychopathology.Nature communications · 2026Article
- Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology.Schizophrenia bulletin · 2025Article
- Alzheimer's Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset.Research square · 2025Article
- Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder.JAMA psychiatry · 2025Article
- Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dysregulation of myelination-related genes in schizophrenia.Journal of neurochemistry · 2024Review
- Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia.Molecular neurobiology · 2024Article
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2024Article
- Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.Biological psychiatry · 2024Article
- Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia.Schizophrenia bulletin · 2024Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Review
- Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.Human brain mapping · 2023Article
- Association of cortical thickness and cognition with schizophrenia treatment resistance.Psychiatry and clinical neurosciences · 2023Article
- Resting-state functional MRI in treatment-resistant schizophrenia.Frontiers in neuroimaging · 2023Review
Corrections and comments
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Authors and funding
23 authors.
Peter KochunovThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Junchao HuangThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Song ChenThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Yanli LiThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Shuping TanThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Fengmei FanThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Wei FengThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Yunhui WangThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Laura M RowlandThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Anya SavranskyThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Xiaoming DuThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Joshua ChiappelliThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Shuo ChenThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Neda JahanshadThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Paul M ThompsonThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Meghann C RyanThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Bhim AdhikariThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Hemalatha SampathThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Yimin CuiThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Zhiren WangThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Fude YangThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Yunlong TanThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
L Elliot HongThe Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov, Rowland, Savransky, Du, Chiappelli, Shuo Chen, Ryan, Adhikari, Sampath, Hong); the Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Huang, Song Chen, Li, S. Tan, Fan, Feng, Y. Wang, Z. Wang, Yang, Y. Tan); Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Marina del Rey, Calif. (Jahanshad, Thompson); and the Department of Pharmacy, Peking University First Hospital, Beijing (Cui).
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MMultidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3MAmish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3MTowards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7MA Multivariate Mediation and Deep Learning Framework for Genome-Connectome -Substance Use ResearchDP1DA048968 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEN, SHUO · 2019 to 2023
$2.3MThe Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia SpectrumR01MH112180 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2017 to 2021
$1.0MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kNIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIDA NIH HHS DP1 DA048968NIH HHS S10 OD023696NIMH NIH HHS R01 MH112180NIMH NIH HHS R01 MH116948NIMH NIH HHS T32 MH067533NIMH NIH HHS U01 MH108148
Abstract
objectiveFailure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes of treatment resistance are unknown, but it is associated with earlier age at onset and more severe cognitive deficits. The authors tested the hypothesis that white matter deficits that are involved in both neurodevelopment and severity of cognitive deficits in schizophrenia are associated with a higher risk of treatment resistance.
methodsThe study sample (N=122; mean age, 38.2 years) included schizophrenia patients at treatment initiation (N=45), patients whose symptoms were treatment responsive (N=40), and patients whose symptoms were treatment resistant (N=37), as well as healthy control subjects (N=78; mean age, 39.2 years). White matter regional vulnerability index (RVI) was tested as a predictor of treatment resistance and cognitive deficits. Higher RVI is indicative of better agreement between diffusion tensor imaging fractional anisotropy across the brain in an individual and the pattern identified by the largest-to-date meta-analysis of white matter deficits in schizophrenia.
resultsPatients with treatment-resistant symptoms showed the highest white matter RVI (mean=0.38 [SD=0.2]), which was significantly higher than the RVI among patients with treatment-responsive symptoms (mean=0.30 [SD=0.02]). At the onset of treatment, schizophrenia patients showed significantly higher RVI than healthy control subjects (mean=0.18 [SD=0.03] and mean=0.13 [SD=0.02], respectively). RVIs were significantly correlated with performance on processing speed and negative symptoms.
conclusionsSchizophrenia affects white matter microstructure in specific regional patterns. Susceptibility to white matter regional deficits is associated with an increased likelihood of treatment resistance. Developments to overcome schizophrenia treatment resistance should consider white matter as an important target.
Indexed as
AdultAntipsychotic AgentsCase-Control StudiesCognitive DysfunctionFemaleHumansMaleMiddle AgedSchizophreniaTreatment FailureWhite MatterAntipsychotic AgentsMagnetic Resonance ImagingSchizophrenia
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