Evidence map›Paper›PMID 31352717›Full record

ArticleThe Korean journal of internal medicine2020

Prognostic implications of stromal hyaluronic acid protein expression in resected oropharyngeal and oral cavity cancers.

Der Sheng Sun, Hye Sung Won, Soon Auck Hong, Ji Hyung Hong, Heejoon Jo, Heejin Lee, Okran Kim, Myung Ah Lee, Yoon Ho Ko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Der Sheng SunDivision of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hye Sung WonDivision of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Soon Auck HongDepartment of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Ji Hyung HongDivision of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Heejoon JoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heejin LeeCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Okran KimCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Myung Ah LeeDivision of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yoon Ho KoDivision of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KRSoonchunhyang University · KRUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsHyaluronic acid (HA) regulates cell adhesion, migration and proliferation in various cancers. The clinical implications of HA in resected head and neck squamous cell carcinoma have not been elucidated. We investigated the clinical significance and prognostic value of the expression of tumoral and stromal HA and its related proteins in oropharyngeal and oral cavity cancer.

methodsResected tissues from oropharyngeal or oral cavity cancer patients undergoing surgery were analysed in tissue microarrays divided into stroma and cancer panels. The expression levels of HA, HA synthases and hyaluronidases were also assessed by immunohistochemistry.

resultsA total of 160 resected oropharyngeal or oral cavity cancer tissues were analysed. Stromal HA expression was observed more frequently in human papilloma virus (HPV)-negative tumors, but other clinicopathological characteristics did not differ. In patients with HPV-negative oral cavity cancers, high stromal HA expression was associated with significantly shorter recurrence-free survival and overall survival compared with low stromal HA expression. The expression of HA in both tumors and stroma was significantly correlated with poorer outcomes than other combinations in patients with HPV-negative oral cavity cancers. However, these prognostic roles of HA were not observed in patients with HPV-negative oropharyngeal cancers. In the HPV-stratified multivariate analysis, high stromal HA expression remained an independent indicator of poor prognosis in terms of recurrence-free survival.

conclusionHigh stromal HA and expression of HA in both tumors and stroma were correlated with poor prognosis in HPV-negative oral cavity cancer, but not in HPV-negative oropharyngeal cancers.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsHumansHyaluronic AcidMouthPrognosisHyaluronic AcidHead and neck neoplasmsHuman papillomavirusHyaluronic acidPrognosisStroma

Identifiers

PMID31352717
PMCPMC7061007
OpenAlexW2966671736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.