Evidence map›Paper›PMID 31352709›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2019

Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study.

Young Sup Woo, Bo-Hyun Yoon, Bong-Hee Jeon, Jeong Seok Seo, Beomwoo Nam, Sang-Yeol Lee, Young-Myo Jae, Sae-Heon Jang, Hun Jeong Eun, Seung-Hee Won and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Young Sup WooDepartment of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Bo-Hyun YoonDepartment of Psychiatry, Naju National Hospital, Naju, Korea.ORCID http://orcid.org/0000-0002-3882-7930
Bong-Hee JeonDepartment of Psychiatry, Naju National Hospital, Naju, Korea.
Jeong Seok SeoDepartment of Psychiatry, School of Medicine, Konkuk University, Chungju, Korea.
Beomwoo NamDepartment of Psychiatry, School of Medicine, Konkuk University, Chungju, Korea.
Sang-Yeol LeeDepartment of Psychiatry, Wonkwang University School of Medicine, Iksan, Korea.
Young-Myo JaeDepartment of Psychiatry, Bongseng Memorial Hospital, Busan, Korea.
Sae-Heon JangDepartment of Psychiatry, Bongseng Memorial Hospital, Busan, Korea.
Hun Jeong EunDepartment of Neuropsychiatry, Presbyterian Medical Center-Jesus Hospital, Jeonju, Korea.
Seung-Hee WonDepartment of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea.
Kwanghun LeeDepartment of Psychiatry, College of Medicine, Dongguk University, Gyeongju, Korea.
Jonghun LeeDepartment of Psychiatry, School of Medicine, Catholic University of Daegu, Daegu, Korea.
Won-Myong BahkDepartment of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID http://orcid.org/0000-0002-0156-2510
BongSeng Memorial Hospital · KRCatholic University of Korea · KRKonkuk University · KRNaju National Hospital · KRDaegu Catholic University · KRDongguk University · KRKyungpook National University · KRPresbyterian Medical Center · KRWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was performed to investigate the efficacy and tolerability of blonanserin in schizophrenic patients who were previously treated with other antipsychotics but, due to insufficient response, were switched to blonanserin.

methodsA total of 52 patients with schizophrenia who were unresponsive to treatment with antipsychotic monotherapy or combination therapy were recruited into this 12-week, open-label, prospective, multicenter study. Patients were switched to blonanserin from their existing antipsychotics over a maximum 2-week tapering-off period. Efficacy was primarily evaluated using the 18-item Brief Psychiatric Rating Scale (BPRS). Assessments were performed at baseline, and at weeks 1, 2, 4, 8, and 12.

resultsSwitching to blonanserin resulted in a significant decrease in the mean total score on the BPRS from baseline (56.8 ± 9.4) to week 12 (42.1 ± 13.8,

conclusionThe results of the present study suggest that switching to blonanserin may be an effective strategy for schizophrenic patients unresponsive to other antipsychotic treatments.

Indexed as

BlonanserinBody weight.ProlactinTreatment outcome

Identifiers

PMID31352709
PMCPMC6705098
OpenAlexW2966840677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.