ArticleEndocrinology, diabetes & metabolism case reports2019
Management of severe hypertriglyceridemia due to lipoprotein lipase deficiency in children
Article in Endocrinology, diabetes & metabolism case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Therapeutic plasmapheresis in a young infant with severe hypertriglyceridemia: a case report.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
- Targeting Triglycerides: The Rise of Apolipoprotein C3 and Angiopoietin-Like Protein 3 Inhibitors.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- Clinical Management of Dyslipidemia in Infants and Toddlers.Current atherosclerosis reports · 2025Review
- Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis.Endocrinology, diabetes & metabolism case reports · 2025Article
- [A case of neonatal-onset type I hyperlipoproteinemia with bloody ascites].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Long-Term Treatment of Lipoprotein Lipase Deficiency with Medium-Chain Triglyceride-Enriched Diet: A Case Series.Nutrients · 2023Article
- Diagnosis of Acute Pancreatitis Secondary to Hypertriglyceridemia in a Pediatric Patient in the Emergency Department.Cureus · 2023Article
- Management strategy and novel ophthalmological findings in neonatal severe hypertriglyceridemia: a case report and literature review.Lipids in health and disease · 2021Review
- White Serum - A Clue to Diagnosis of Acute Recurrent Pancreatitis.Indian journal of pediatrics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Summary: Severe hypertriglyceridemia is an endocrine emergency and is associated with acute pancreatitis and hyperviscosity syndrome. We describe an infant with lipoprotein lipase deficiency with severe hypertriglyceridemia who presented with acute pancreatitis. She was managed acutely with fasting and intravenous insulin infusion, followed by low-fat diet with no pharmacological agent. Subsequent follow-up until the age of 5 years showed satisfactory lipid profile and she has normal growth and development. Learning Points: Hypertriglyceridemia-induced acute pancreatitis has significant morbidity and mortality, and prompt treatment is imperative. When no secondary causes are readily identified, genetic evaluation should be pursued in hypertriglyceridemia in children. Intravenous insulin is a safe and effective acute treatment for hypertriglyceridemia in children, even in infants. Long-term management with dietary modifications alone could be effective for primary hypertriglyceridemia due to lipoprotein lipase deficiency, at least in early childhood phase.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.