ArticleJournal of sleep research2020
Effects of deep sedation on sleep in critically ill medical patients on mechanical ventilation.
Article in Journal of sleep research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Music intervention for sleep quality in critically ill and surgical patients: a meta-analysis.BMJ open · 2021Pooled it
- Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus.Annals of clinical and translational neurology · 2026Article
- Characteristics and Risk Factors for Delirium in Critically Ill Cardiac Surgery Patients: An Observational Study.Nursing reports (Pavia, Italy) · 2026Article
- Effect of sleep quality on weaning from mechanical ventilation: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- Awake venovenous extracorporeal membrane oxygenation and survival.Frontiers in medicine · 2024Article
- Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial.Journal of intensive care · 2023Article
- Sleep during and following critical illness: A narrative review.World journal of critical care medicine · 2023Review
- The effect of preoperative sleep quality on the target plasma concentration of propofol and postoperative sleep in patients undergoing painless gastroscopy.BMC anesthesiology · 2023Article
- Sleep and critical illness: a review.Frontiers in medicine · 2023Review
- Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation.BMC pediatrics · 2022Article
- Adding Insult to Injury: Sleep Deficiency in Hospitalized Patients.Clinics in chest medicine · 2022Review
- Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies.Critical care explorations · 2022Review
- Article
- Observational
- Family automated voice reorientation (FAVoR) intervention for mechanically ventilated patients in the intensive care unit: Study protocol for a randomized controlled trial.Contemporary clinical trials · 2021Article
- The clinical value of comprehensive nursing intervention in preventing ventilator-associated pneumonia.American journal of translational research · 2021Article
- Effects of deep sedation on sleep in critically ill medical patients on mechanical ventilation.Journal of sleep research · 2020Article
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical EEG patterns not consistent with standard sleep staging criteria have been observed in medical intensive care unit (ICU) patients. Our aim was to examine the relationship between sleep architecture and sedation in critically ill mechanically ventilated patients pre- and post-extubation. We performed a prospective observational repeated measures study where 50 mechanically ventilated patients with 31 paired analyses were examined at an academic medical centre. The sleep efficiency was 58.3 ± 25.4% for intubated patients and 45.6 ± 25.4% for extubated patients (p = .02). Intubated patients spent 76.33 ± 3.34% of time in non-rapid eye movement (NREM) sleep compared to 64.66 ± 4.06% of time for extubated patients (p = .02). REM sleep constituted 1.36 ± 0.67% of total sleep time in intubated patients and 2.06 ± 1.09% in extubated patients (p = .58). Relative sleep atypia was higher in intubated patients compared to extubated patients (3.38 ± 0.87 versus 2.79 ± 0.42; p < .001). Eleven patients were sedated with propofol only, 18 patients with fentanyl only, 11 patients with fentanyl and propofol, and 10 patients had no sedation. The mean sleep times on "propofol", "fentanyl", "propofol and fentanyl," and "no sedation" were 6.54 ± 0.64, 4.88 ± 0.75, 6.20 ± 0.75 and 4.02 ± 0.62 hr, respectively. The sigma/alpha values for patients on "propofol", "fentanyl", "propofol and fentanyl" and "no sedation" were 0.69 ± 0.04, 0.54 ± 0.01, 0.62 ± 0.02 and 0.57 ± 0.02, respectively. Sedated patients on mechanical ventilation had higher sleep efficiency and more atypia compared to the same patients following extubation. Propofol was associated with higher sleep duration and less disrupted sleep architecture compared to fentanyl, propofol and fentanyl, or no sedation.
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