ArticleRheumatology international2020
Evaluation of co-existing diseases in children with familial Mediterranean fever.
Article in Rheumatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Long-term clinical course of pediatric familial Mediterranean fever with heterozygous pathogenic MEFV exon 10 variants.European journal of pediatrics · 2026Article
- Clinical spectrum of pediatric patients carrying heterozygous MEFV gene variants.European journal of pediatrics · 2026Article
- Beyond genotype: clustering analysis highlights clinical heterogeneity in paediatric familial Mediterranean fever.RMD open · 2026Article
- From diagnosis to treatment response: predicting FMF50 response using PREDICT-crFMF and TURPAID scores in children with Familial Mediterranean Fever: a retrospective cohort study.Clinical rheumatology · 2026Article
- Depression and sleep disturbances in children and adolescents with familial Mediterranean fever: a prospective case-control study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Inflammatory bowel disease in paediatric rheumatological diseases.Clinical rheumatology · 2025Article
- Associated diseases and their effects on disease course in patients with chronic non-bacterial osteomyelitis: retrospective experience from a single center.Clinical rheumatology · 2025Article
- Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database.Frontiers in immunology · 2025Article
- Co-occurrence of autoimmune diseases and metabolic disorders in familial mediterranean fever patients: review of literature and case reports.Frontiers in immunology · 2025Review
- Familial Mediterranean Fever in Childhood.Turkish archives of pediatrics · 2024Review
- Article
- The Impact of Different MEFV Genotypes on Clinical Phenotype of Patients with Familial Mediterranean Fever: Special Emphasis on Joint Involvement.European journal of pediatrics · 2024Article
- Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever.Clinical and experimental immunology · 2024Article
- Inflammatory comorbidities ın the largest pediatric Familial Mediterranean fever cohort: a multicenter retrospective study of Pediatric Rheumatology Academy (PeRA)-Research Group (RG).Clinical rheumatology · 2024Article
- Genotype Mutations in Palestinian Children with Familial Mediterranean Fever: Clinical Profile, and Response to Colchicine Treatment: A Retrospective Cohort Study.Mediterranean journal of rheumatology · 2023Article
- Evaluation of retinal and optic disc vascular structures in patients with familial Mediterranean fever (FMF) via optical coherence tomography angiography.International ophthalmology · 2023Article
- Non-Rheumatic Chronic Comorbidities in Children with Juvenile Idiopathic Arthritis.Turkish archives of pediatrics · 2023Article
- Familial Mediterranean fever in Armenian children with inflammatory bowel disease.Frontiers in pediatrics · 2023Article
- Spondyloarthritis in familial Mediterranean fever: a cohort study.Rheumatology international · 2022Article
- Comparisons of Clinical Features and Outcomes of COVID-19 between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial Mediterranean fever (FMF) is A common periodic fever syndrome. The causative gene of the FMF is named Mediterranean Fever gene (MEFV). Increased inflammation in FMF may play a role as a trigger for the development of some diseases. The objective of the study is to evaluate the frequency of comorbid disorders in children followed up with diagnosis of FMF. Additionally, we aimed to assess the association between FMF and other inflammatory conditions in a large pediatric FMF cohort. A total of 686 FMF patients were included in the cross-sectional study. A questionnaire including questions about characteristics of fever episodes, presence of arthralgia, arthritis, abdominal pain, chest pain during and co-existence of any other disease diagnosed by a physician was filled out by face-to-face interviews with patients or their parents. Female-male ratio was 0.85. Median age at the time of study, age at disease onset and at the time of diagnosis were 12.9 (1.7-22.3), 3 (0.08-17), and 6 (0.75-17) years, respectively. In 130 (18.9%) FMF patients we detected co-existing inflammatory condition. The most common co-existing diseases were: juvenile idiopathic arthritis 42 (6.1%), asthma/reactive airway disease 29 (4.2%), Henoch-Schönlein purpura 20 (2.9%), uveitis 12 (1.7%) and inflammatory bowel disease 10 (1.4%). Except for asthma/reactive airway disease and inflammatory bowel disease, there was no significant difference regarding the type of MEFV gene mutation. We have reported increased frequencies of various inflammatory conditions and decreased frequency of asthma in patients with FMF.
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