ArticleCellular and molecular life sciences : CMLS2020
Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia.
Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Chiropteran (Animals : an open access journal from MDPI · 2026Article
- Precision arbovirus serology with a pan-arbovirus peptidome.Nature communications · 2024Article
- Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints.Nature communications · 2024Article
- Serological and molecular detection of dengue virus in animals: A systematic review and meta-analysis.Le infezioni in medicina · 2024Review
- Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses.Frontiers in public health · 2023Article
- Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology.Pathogens (Basel, Switzerland) · 2022Review
- Article
- Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus.Virus genes · 2021Article
- Animals as potential reservoirs for dengue transmission: A systematic review.One health (Amsterdam, Netherlands) · 2021Review
- The detection of Japanese encephalitis virus in Megachiropteran bats in West Kalimantan, Indonesia: A potential enzootic transmission pattern in the absence of pig holdings.International journal for parasitology. Parasites and wildlife · 2021Article
- RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.Cell host & microbe · 2020Article
- Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.Cell reports · 2020Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Natural reservoir hosts can sustain infection of pathogens without succumbing to overt disease. Multiple bat species host a plethora of viruses, pathogenic to other mammals, without clinical symptoms. Here, we detail infection of bat primary cells, immune cells, and cell lines with Dengue virus. While antibodies and viral RNA were previously detected in wild bats, their ability to sustain infection is not conclusive. Old-world fruitbat cells can be infected, producing high titres of virus with limited cellular responses. In addition, there is minimal interferon (IFN) response in cells infected with MOIs leading to dengue production. The ability to support in vitro replication/production raises the possibility of bats as a transient host in the life cycle of dengue or similar flaviviruses. New antibody serology evidence from Asia/Pacific highlights the previous exposure and raises awareness that bats may be involved in flavivirus dynamics and infection of other hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.