ArticleNaunyn-Schmiedeberg's archives of pharmacology2019
Effects of diosmin and crocin on metabolic syndrome-associated cardio-vascular complications in rats.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Factors influencing baseline electrocardiographic parameters in rats: A systematic review of experimental studies published from 1960 to the present.Physiological reports · 2026Pooled it
- Diosmin Attenuates Age-Associated Vascular Oxidative Stress and Endothelial Dysfunction in Aged Rats.Foods (Basel, Switzerland) · 2026Article
- Renoprotective effect of diosmin against chlorpyrifos-induced kidney injury is mediated by the regulation of TLR4/HMGB1/NF-κB, PPAR-γ/SIRT1, and Bax/Bcl2 signals.Journal of molecular histology · 2025Article
- Diosmin or Hesperidin? Comparison of Antioxidative Action of Two Venoactive Flavonoids in Type 1 Diabetic Rats.International journal of molecular sciences · 2025Article
- Effects of Crocus sativus on glycemic control and cardiometabolic parameters among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Nutrition & metabolism · 2024Review
- The Synthetic Flavonoid Hidrosmin Improves Endothelial Dysfunction and Atherosclerotic Lesions in Diabetic Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review.European journal of drug metabolism and pharmacokinetics · 2022Review
- Crocin enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress.American journal of translational research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to scrutinize the potential protective effect of diosmin and crocin against cardio-vascular complications attributed to metabolic syndrome (MS). For 16 weeks, the rats were given 10% fructose in water and 3% salt in diet to induce MS over a 16-week period. At week 7 and for 10 weeks, diosmin (50 mg/kg, PO) or crocin (50 mg/kg, PO) was administered daily. Non-invasive blood pressure (BP) was recorded in conscious animals. Thoracic aorta (macro vessels) and kidney (micro vessels) concentration-response curves for phenylephrine (PE) and acetylcholine (ACh) were analyzed. Electrocardiogram (ECG) parameters were recorded. Blood glucose level, serum insulin level, troponin T, advanced glycation end products (AGEs), malondialdehyde (MDA), and tumor necrosis factor-α (TNF-α) were measured. In addition, histological examination of aorta and heart tissues was performed. Diosmin and crocin alleviated cardio-vascular complications associated with MS. This is manifested in improvement of systolic and diastolic BP and ECG parameters. They ameliorated MS-induced exaggerated contractility to PE and improved the impaired dilatation to Ach in macro and micro vasculature. Diosmin and crocin reduced the elevated serum levels of insulin, AGEs, TNF-α, and MDA and reversed MS-induced structural changes of aorta and cardiac tissues. Diosmin and crocin offset the cardiac changes and vascular impairment associated with MS via attenuation of oxidative stress and suppression of inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.