Evidence map›Paper›PMID 31352437›Full record

ArticleAging2019

Aberrant DNA methylation of synaptophysin is involved in adrenal cortisol-producing adenoma.

Jia-Yu Zhong, Rong-Rong Cui, Xiao Lin, Feng Xu, Ting Zhu, Fuxingzi Li, Feng Wu, En Zhou, Lu Yi, Ling-Qing Yuan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jia-Yu ZhongDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Rong-Rong CuiDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xiao LinDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Feng XuDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Ting ZhuDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Fuxingzi LiDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Feng WuDepartment of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
En ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, People's Republic of China.
Lu YiDepartment of Urology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Ling-Qing YuanDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Central South University · CNHunan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortisol-producing adenoma (CPA) is the main cause of Adrenal Cushing syndrome. However, its molecular mechanism is not fully understood. Previous study revealed Synaptophysin (

Indexed as

DNA MethylationAdrenal Cortex NeoplasmsAdrenocortical AdenomaAdultCell Line, TumorDioxygenasesFemaleGene Knockdown TechniquesGene TargetingHumansHydrocortisoneMaleMicroRNAsMiddle AgedSignal TransductionSynaptophysinDioxygenasesHydrocortisoneMicroRNAsMIRN27 microRNA, humanSynaptophysinSYP protein, humanTET3 protein, humanadrenal cortisol-producing adenomaDNA methylationmicroRNAsynaptophysin

Identifiers

PMID31352437
PMCPMC6682529
OpenAlexW2965033352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.