ReviewJournal of investigative medicine : the official publication of the American Federation for Clinical Research2019
Viruses and non-allergen environmental triggers in asthma.
Review in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05292586 (A 12 Week, Randomized, Double-blind, Multicenter, Active Controlled, 2-Arm Parallel Group Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 12 Week, Randomized, Double-blind, Multicenter, Active Controlled, 2-Arm Parallel Group Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose (Fixed Combination of Extrafine Beclomethasone Dipropionate Plus Formoterol Fumarate) Compared to CHF 718 pMDI 800µg Total Daily Dose (Extrafine Beclomethasone Dipropionate) in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Randomised Controlled Trial Comparing Single Maintenance and Reliever Therapy (SMART) with Inhaled Budesonide-Formoterol Combination, Versus Conventional Budesonide and Additional As-Needed Levo-Salbutamol, in Children with Persistent Bronchial Asthma.Indian journal of pediatrics · 2026Trial
- Natural medicines for asthma management: mechanisms aligned with endotypes and multi-dimensional intervention.Frontiers in pharmacology · 2026Review
- Non-T2 asthma.Current opinion in pulmonary medicine · 2025Review
- Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action.Journal of asthma and allergy · 2025Review
- Changes in asthma emergency department visits in the United States during the COVID-19 pandemic.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Clinical implications of asthma endotypes and phenotypes.Allergy and asthma proceedings · 2022Article
- Trained immunity in type 2 immune responses.Mucosal immunology · 2022Review
- The Association between the Occurrence of Asthma and Antecedents of Exposure to Environmental Tobacco Smoke in the Previous Year in Children: An Incidence-Density Study.International journal of environmental research and public health · 2022Article
- Viral Infection and Respiratory Exacerbation in Children: Results from a Local German Pediatric Exacerbation Cohort.Viruses · 2022Article
- Microbiome Research and Multi-Omics Integration for Personalized Medicine in Asthma.Journal of personalized medicine · 2021Review
- Different effects of smoking on atopic and non-atopic adult-onset asthma.Clinical and translational allergy · 2021Article
- Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases.Microorganisms · 2021Review
- Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment.Metabolites · 2021Review
- Pediatric Asthma Exacerbation in Children with Suspected and Confirmed Coronavirus Disease 2019 (COVID-19): An Observational Study from Saudi Arabia.Journal of asthma and allergy · 2021Article
- Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma.Frontiers in immunology · 2021Review
- Investigation of the Mechanisms of Chuankezhi Injection in the Treatment of Asthma Based on the Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Insights Into Type I and III Interferons in Asthma and Exacerbations.Frontiers in immunology · 2020Review
- Biological Therapies of Severe Asthma and Their Possible Effects on Airway Remodeling.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.