ReviewBiochimica et biophysica acta. Molecular and cell biology of lipids2020
Spatial compartmentalization of lipid droplet biogenesis.
Review in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Single-Cell Transcriptomics Reveals the FA9-VAP Module Regulating Fatty Acid Accumulation in Soybean Seeds.Plant biotechnology journal · 2026Article
- Decoding the Lipid Droplet Proteome: New Frontiers in Cardiovascular Disease Research.International journal of molecular sciences · 2025Review
- The jojoba lipid droplet protein LDAP1 facilitates the packaging of wax esters into lipid droplets.The Plant cell · 2025Article
- Gestational Diabetes-like Fuels Impair Mitochondrial Function and Long-Chain Fatty Acid Uptake in Human Trophoblasts.International journal of molecular sciences · 2024Article
- Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases.Chinese medicine · 2024Review
- The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.Journal of translational medicine · 2024Review
- Comparative analysis of transcriptome in oil biosynthesis between seeds and non-seed tissues ofFrontiers in plant science · 2024Article
- Concept of lipid droplet biogenesis.European journal of cell biology · 2023Review
- Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions.Inflammation · 2023Review
- Compartmentalization engineering of yeasts to overcome precursor limitations and cytotoxicity in terpenoid production.Frontiers in bioengineering and biotechnology · 2023Review
- Perilipin 3 promotes the formation of membrane domains enriched in diacylglycerol and lipid droplet biogenesis proteins.Frontiers in cell and developmental biology · 2023Article
- Genome-wide analysis revealed the stepwise origin and functional diversification of HSDs from lower to higher plant species.Frontiers in plant science · 2023Article
- Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation.The Journal of cell biology · 2022Article
- TOR complex 2 is a master regulator of plasma membrane homeostasis.The Biochemical journal · 2022Article
- DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.The EMBO journal · 2022Article
- Seipin collaborates with the ER membrane to control the sites of lipid droplet formation.Current opinion in cell biology · 2022Review
- Lipid Droplets in Cancer: From Composition and Role to Imaging and Therapeutics.Molecules (Basel, Switzerland) · 2022Review
- Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury.Frontiers in cellular neuroscience · 2022Review
- Lipid Droplets, Phospholipase ABiomedicines · 2021Review
- Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat.Developmental cell · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Lipid droplets (LDs) are ubiquitous organelles that store metabolic energy in the form of neutral lipids (typically triacylglycerols and steryl esters). Beyond being inert energy storage compartments, LDs are dynamic organelles that participate in numerous essential metabolic functions. Cells generate LDs de novo from distinct sub-regions at the endoplasmic reticulum (ER), but what determines sites of LD formation remains a key unanswered question. Here, we review the factors that determine LD formation at the ER, and discuss how they work together to spatially and temporally coordinate LD biogenesis. These factors include lipid synthesis enzymes, assembly proteins, and membrane structural requirements. LDs also make contact with other organelles, and these inter-organelle contacts contribute to defining sites of LD production. Finally, we highlight emerging non-canonical roles for LDs in maintaining cellular homeostasis during stress.
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