ArticleInternational journal of radiation oncology, biology, physics2019
Salivary Metabolomics of Total Body Irradiated Nonhuman Primates Reveals Long-Term Normal Tissue Responses to Radiation.
Article in International journal of radiation oncology, biology, physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Polymeric sorbent phase sorptive extraction for radiation metabolomics.RSC advances · 2026Article
- Long-term Radiation Signal Persistence in Urine and Blood: A Two-year Analysis in Non-human Primates Exposed to a 4 Gy Total-Body Gamma-Radiation Dose.Radiation research · 2025Article
- Multicentered Biospecimen Analyses after 4 Gy Sublethal Total Body Irradiation in Rhesus Macaques.Radiation research · 2025Article
- Integrating deep learning and molecular dynamics simulations for FXR antagonist discovery.Molecular diversity · 2025Article
- Applicability of Gene Expression in Saliva as an Alternative to Blood for Biodosimetry and Prediction of Radiation-induced Health Effects.Radiation research · 2024Article
- Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.BMC genomics · 2023Article
- The NIAID/RNCP Biodosimetry Program: An Overview.Cytogenetic and genome research · 2023Review
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure.Journal of translational medicine · 2022Article
- NIH Policies and Regulatory Pathways to U.S. FDA licensure: Strategies to Inform Advancement of Radiation Medical Countermeasures and Biodosimetry Devices.Radiation research · 2022Article
- Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model.Frontiers in oncology · 2022Article
- NIH Policies and Regulatory Pathways for the Advancement of Radiation Medical Countermeasures and Biodosimetry Tools to U.S. FDA Licensure.Radiation research · 2021Article
- Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction.Physiological genomics · 2021Article
- Urine metabolomics based prediction model approach for radiation exposure.Scientific reports · 2020Article
- Metabolomics in Radiation Biodosimetry: Current Approaches and Advances.Metabolites · 2020Review
- Development of the FAST-DOSE assay system for high-throughput biodosimetry and radiation triage.Scientific reports · 2020Article
- A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury.Metabolites · 2020Review
- An optimised saliva collection method to produce high-yield, high-quality RNA for translational research.PloS one · 2020Article
- Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTo identify metabolomic biomarkers of acute radiation exposure in saliva that show time-dependent changes. METHODS AND MATERIALS: Nonhuman primates were exposed to 4 Gy of total body irradiation with γ-rays. Saliva was collected from 7 animals twice before and at days 1, 3, 5, 7, 15, 21, 28, and 60 after irradiation. Profiling was conducted with liquid chromatography time-of-flight mass spectrometry. Multivariate data analysis and potential biomarker identification was conducted through random Forests and the software MetaboAnalyst. Candidate biomarkers were validated through tandem mass spectrometry, and receiver operating characteristic curves were constructed to show the diagnostic ability of the signature over time.
resultsUntargeted metabolomic analysis revealed significant and persistent effects up to the 60 days evaluated in this study. Biomarkers spanning primarily amino acids and nucleotides were identified, with a significant number showing long-term responses. Fifteen biomarkers showed high statistical significance in the first week after irradiation and 16 at >7 days after irradiation (false discovery rate-adjusted P < .05). The combination of the biomarkers in a single biosignature was able to accurately show the diagnostic ability of the signature in a binary classifier system with receiver operating characteristic curves.
conclusionsRadiation can alter the metabolome in saliva, and metabolomics could effectively be used to monitor radiation responses, as a biodosimetry method, in the event of a radiological incident. Saliva metabolomics also has potential relevance in a clinical setting.
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