ReviewCellular and molecular gastroenterology and hepatology2020
Etiopathogenetic Mechanisms in Diverticular Disease of the Colon.
Review in Cellular and molecular gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Genetic, epigenetic and environmental factors in diverticular disease: systematic review.BJS open · 2024Pooled it
- Natural Language Processing Algorithm Accurately Classifies Diverticulitis-Related Complications and Predicts Long-Term Outcomes.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Progression rate of diverticular disease and associated risk factors: results from 5-year longitudinal prospective nationwide diverticular disease registry (REMAD).Internal and emergency medicine · 2026Article
- Clinical and Economic Insights Into Surgery for Colonic Diverticular Perforation: A Long-Term Observational Cohort Study.Annals of gastroenterological surgery · 2025Article
- The function of chloride channels in digestive system disease (Review).International journal of molecular medicine · 2025Review
- Look inside the management of colonic diverticular rebleeding: a systematic review.Therapeutic advances in gastroenterology · 2025Review
- Complicated Sigmoid Diverticulitis Mimicking Pelvic Pain in a Patient With Giant Uterine Fibroids: A Case Report.Cureus · 2025Article
- The Unexplored Role of Mitochondria-Related Oxidative Stress in Diverticular Disease.International journal of molecular sciences · 2024Article
- Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study.Scientific reports · 2024Article
- Is there a link between appendicitis and the risk of diverticular disease?: a large German cohort study.International journal of colorectal disease · 2024Article
- Serotonin Metabolism and Serotonin Receptors Expression Are Altered in Colon Diverticulosis.Medicina (Kaunas, Lithuania) · 2023Article
- Diverticular Disease Worsening Is Associated with Increased Oxidative Stress and Gut Permeability: New Insights by Circulating Biomarkers.Antioxidants (Basel, Switzerland) · 2023Article
- Gene Identification in Inflammatory Bowel Disease via a Machine Learning Approach.Medicina (Kaunas, Lithuania) · 2023Article
- Colorectal endoscopic submucosal dissection using the water pressure method for diverticulum-associated lesions: A case series study (with video).Endoscopy international open · 2023Article
- Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management.Clinical and experimental gastroenterology · 2023Review
- Pathophysiology of Diverticular Disease: From Diverticula Formation to Symptom Generation.International journal of molecular sciences · 2022Review
- Colonic Diverticulosis Is Not Associated With Painful Abdominal Symptoms in a US Population.Gastro hep advances · 2022Article
- Evaluation of molecular and genetic predisposing parameters at diverticular disease of the colon.International journal of colorectal disease · 2021Review
- Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease.Journal of neurogastroenterology and motility · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This article reviews epidemiological evidence of heritability and putative mechanisms in diverticular disease, with greatest attention to 3 recent studies of genetic associations with diverticular disease based on genome-wide or whole-genome sequencing studies in large patient cohorts. We provide an analysis of the biological plausibility of the significant associations with gene variants reported and highlight the relevance of ANO1, CPI-17 (aka PPP1R14A), COLQ6, COL6A1, CALCB or CALCA, COL6A1, ARHGAP15, and S100A10 to colonic neuromuscular function and tissue properties that may result in altered compliance and predispose to the development of diverticular disease. Such studies also identify candidate genes for future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.