ArticleBehavioural brain research2019
Nucleus reuniens mediates the extinction of contextual fear conditioning.
Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Article
- Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.Molecular psychiatry · 2025Article
- Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans.Communications biology · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Article
- Activation patterns in male and female forebrain areas during habituation to food and context novelty.Brain structure & function · 2025Article
- A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.bioRxiv : the preprint server for biology · 2025Article
- The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep.eLife · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- Nucleus reuniens: Modulating emotional overgeneralization in peri-adolescents with anxiety.Cognitive, affective & behavioral neuroscience · 2025Article
- Article
- Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal.Journal of neurochemistry · 2025Article
- Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex.Frontiers in neural circuits · 2025Article
- The Emerging Role of Brain Mitochondria in Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Mystery of the memory engram: History, current knowledge, and unanswered questions.Neuroscience and biobehavioral reviews · 2024Review
- A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination.Nature communications · 2023Article
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2 authors.
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Abstract
Learning and remembering the context in which events occur requires interactions between the hippocampus (HPC) and medial prefrontal cortex (mPFC). The nucleus reuniens (RE) is a ventral midline thalamic nucleus that coordinates activity in the mPFC and HPC and is involved in spatial and contextual memory. We recently found that the RE is critical for contextual fear conditioning in rats, a form of learning that involves interactions between the HPC and mPFC. Here we examined whether the RE mediates the extinction of contextual fear. After contextual fear conditioning, rats underwent an extinction procedure in which they were merely exposed to the conditioning context; freezing behavior during the extinction procedure and during a retrieval test 24 h later served as an index of conditioned fear. Muscimol inactivation of the RE prior to extinction impaired the acquisition of both short- and long-term extinction memories. Similarly, inactivation of the RE prior to the extinction retrieval test also impaired the expression of extinction; this effect was not state-dependent. Taken together, these results reveal that the extinction of contextual fear memories requires the RE, which is consistent with a broader role for the RE in forms of learning that require HPC-mPFC interactions.
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