ArticleNeuron2019
The Cholinergic Basal Forebrain Links Auditory Stimuli with Delayed Reinforcement to Support Learning.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 120 citations in OpenAlex.
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Striatal control of amygdalar acetylcholine release during salience-associated processing.Nature neuroscience · 2026Article
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A non-canonical cholinergic pathway from the dorsal tail of the striatum to the auditory cortex.Nature communications · 2026Article
- Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons.Science advances · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.bioRxiv : the preprint server for biology · 2025Article
- Article
- A disinhibitory microcircuit in the temporal association cortex for fear retrieval to pure tones.Scientific reports · 2025Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes.Science advances · 2025Article
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- Article
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animals learn to fear conditioned sound stimuli (CSs) that accompany aversive unconditioned stimuli (USs). Auditory cortex (ACx) circuits reorganize to support auditory fear learning when CS-evoked activity temporally overlaps with US-evoked acetylcholine release from the basal forebrain. Here we describe robust fear learning and acetylcholine-dependent ACx plasticity even when the US is delayed by several seconds following CS offset. A 5-s CS-US gap was not bridged by persistent CS-evoked spiking throughout the trace period. Instead, within minutes following the start of conditioning, optogenetically identified basal forebrain neurons that encode the aversive US scaled up responses to the CS and increased functional coupling with the ACx. Over several days of conditioning, bulk imaging of cholinergic basal forebrain neurons revealed sustained sound-evoked activity that filled in the 5-s silent gap preceding the US. These findings identify a plasticity in the basal forebrain that supports learned associations between sensory stimuli and delayed reinforcement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.