ArticleDiagnostic pathology2019
Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: a case report.
Article in Diagnostic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Classification of intrahepatic cholangiocarcinoma.Abdominal radiology (New York) · 2025Review
- Primary hepatobiliary mucoepidermoid carcinoma: a case report and review of literature.Medical molecular morphology · 2024Review
- Review
- A rare case of easily misdiagnosed primary mucoepidermoid carcinoma of the liver.Genes & diseases · 2022Article
- Primary mucoepidermoid carcinoma of the intrahepatic bile duct: A case report.Clinical case reports · 2022Article
- Cutaneous Melanocytic Tumor withBiology · 2021Review
- Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma.Diagnostic pathology · 2021Article
- Rare Primary Hepatic Mucoepidermoid Carcinoma: A Report of Two Cases.Case reports in oncologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundCRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course. Primary MEC of the liver is an extremely rare, aggressive tumor, and no study has investigated CRTC1-MAML2 fusion. CASE PRESENTATION: A 79-year-old Japanese female presented with an approx. 5-cm hepatic mass lesion. We surgically resected the lesion under the clinical diagnosis of intrahepatic cholangiocarcinoma. The histological and immunohistochemical findings were consistent with high-grade MEC, consisting of squamoid, mucin-producing, and intermediate tumor cells. Our RT-PCR analysis revealed the presence of CRTC1-MAML2 fusion. This fusion gene was further confirmed by direct sequencing. The patient is still alive almost 10 years after the surgery.
conclusionThis is the first case report of primary MEC of the liver with CRTC1-MAML2 fusion, with long survival. The present case has significant implications for the entity of primary MEC of the liver which should be distinguished from adenosquamous carcinoma.
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