Evidence map›Paper›PMID 31351483›Full record

ArticleEuropean journal of medical research2019

Dok-3 deficient mice display different immune clustering and Tim-3 expression.

Wenjiang Yan, Yijia Tian, Peng Sun, Jingjing Yang, Na Li, Yuanyuan Sun, Shuangxi Wang, Cheng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Wenjiang YanThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China.ORCID http://orcid.org/0000-0003-4032-7983
Yijia TianGrade 2015, School of Basic Medical Sciences, Clinical Medicine(5 + 3), Shandong University, Jinan, Shandong, China.
Peng SunThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China.
Jingjing YangThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China.
Na LiThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China.
Yuanyuan SunThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China.
Shuangxi WangThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China. shuangxiwang@sdu.edu.cn.
Cheng ZhangThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, China. zhangc@sdu.edu.cn.
Qilu Hospital of Shandong University · CNMinistry of Education · BDMinistry of Education · THShandong Tumor Hospital · CNShandong University · CN

Funding

National Natural Science Foundation of China (CN) 81400195National Natural Science Foundation of China (CN) 81500339National Natural Science Foundation of China (CN) 81600344Natural Science Foundation of Shandong Province ZR2016HP01Natural Science Foundation of Shandong Province ZR2016HQ29
6 · The paper itself

Abstract

backgroundDok-3 has been shown to play an important role in immune system. Tim-3 also has been recognized as an important immune regulator which involves in many diseases. The relationship of them is still unclear.

methodsWe detected the expression of Tim-3 on spleen immune cells from Dok-3 deficient mice and control mice by flow cytometry.

resultsIn this article, we found that Dok-3

conclusionsAlthough Dok-3

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDendritic CellsHepatitis A Virus Cellular Receptor 2Killer Cells, NaturalMacrophagesMiceMyeloid-Derived Suppressor CellsAdaptor Proteins, Signal TransducingDok3 protein, mouseHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Dok-3Immune cells proportionTim-3

Identifiers

PMID31351483
PMCPMC6660655
OpenAlexW2965037980

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.