ArticleDrug and alcohol dependence2019
Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06965296 (AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sweet Flavors and the Addictive Potential of E-Cigarettes: A Systematic Narrative Review.European addiction research · 2026Pooled it
- Youth use of e-liquid flavours-a systematic review exploring patterns of use of e-liquid flavours and associations with continued vaping, tobacco smoking uptake or cessation.Addiction (Abingdon, England) · 2022Pooled it
- Effects of commercial unflavored and vanilla-flavored e-liquids on nicotine intake and withdrawal.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal Associations between Adolescent Electronic Cigarette Use and Eating Behaviors.Substance use & misuse · 2025Article
- Recall of Flavor at First E-cigarette Use and Its Association with E-cigarette Progression: The Mediating Effects of First Sensory Experience.The Journal of pediatrics · 2024Article
- E-cigarette dependence and cooling flavor use are linked among youth.Drug and alcohol dependence · 2024Article
- Does Brand Choice Matter: Associations Between Usual E-Cigarette Brands and E-Cigarette Use Patterns Among U.S. Youth, 2021.Health promotion practice · 2024Article
- A clinical overview of adolescent e-cigarette use (vaping).Minerva pediatrics · 2024Article
- Key Risk Factors Associated With Electronic Nicotine Delivery Systems Use Among Adolescents.JAMA network open · 2023Article
- Mutual pathways between peer and own e-cigarette use among youth in the United States: a cross-lagged model.BMC public health · 2023Article
- Beyond the label: current evidence and future directions for the interrelationship between electronic cigarettes and mental health.Frontiers in psychiatry · 2023Review
- E-cigarette addiction and harm perception: Does initiation flavor choice matter?BMC public health · 2022Article
- Dual Use of Nicotine and Cannabis Through Vaping Among Adolescents.American journal of preventive medicine · 2022Article
- Puff Bars, Tobacco Policy Evasion, and Nicotine Dependence: Content Analysis of Tweets.Journal of medical Internet research · 2022Article
- First E-Cigarette Flavor and Device Type Used: Associations With Vaping Persistence, Frequency, and Dependence in Young Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Youth vaping: a review and update on global epidemiology, physical and behavioral health risks, and clinical considerations.European journal of pediatrics · 2022Review
- Young people's e-cigarette risk perceptions, policy attitudes, and past-month nicotine vaping in 30 U.S. cities.Drug and alcohol dependence · 2021Article
- Subjective experiences at e-cigarette initiation: Implications for e-cigarette and dual/poly tobacco use among youth.Addictive behaviors · 2021Article
- Adolescent depression symptoms and e-cigarette progression.Drug and alcohol dependence · 2021Article
- Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation.Neuropharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveE-cigarettes are the most prevalent tobacco product used by adolescents. We sought to determine whether the presence of flavoring and/or the presence of nicotine at the first e-cigarette exposure predicted progression to current e-cigarette use (use in past 30 days) as well as escalation in use (number of days in the past 30 days) among adolescents.
methodsAdolescents from public high schools outside of Philadelphia, PA completed in-classroom surveys at baseline (9
resultsWe employed a two-part Latent Growth Curve Model including flavor, nicotine, and other covariates. Initial use of a flavored (vs unflavored) e-cigarette was associated with progression to current e-cigarette use (β = 0.54, z = 2.09, p = 0.04) and escalation in the number of days of e-cigarette use (β = 0.35, z = 2.58, p = 0.01) across the following 18 months. Initial use of an e-cigarette with nicotine (vs without nicotine) was associated with a greater number of days of e-cigarette use at baseline (β = 0.49, z = 2.16, p = 0.03).
conclusionsThe findings underscore the risk that flavoring and nicotine pose for progression beyond initial e-cigarette use. Regulations addressing flavoring and nicotine in e-cigarettes have the potential to reduce the number of adolescents who become current as well as frequent e-cigarette users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.