ArticleCalcified tissue international1988
Vitamin D metabolism in pregnant and pseudopregnant rats: identification of 25-hydroxycholecalciferol-1-hydroxylase in decidual tissue.
Article in Calcified tissue international, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsTrial
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1 author.
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Abstract
Elevated levels of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are found in late pregnancy but the factors responsible for this are not known. To determine if the maternal-fetal calcium flux or the presence of a previously described extrarenal 25-hydroxycholecalciferol-1-hydroxylase (25(OH)-D3-1-hydroxylase) play a role, serum calcium and 1,25(OH)2D3 were measured in pregnant, nonpregnant, and decidua-bearing pseudopregnant rats. Serum calcium was 8.74 +/- 0.26 mg/dl (mean +/- SEM) in nonpregnant rats. In pregnant rats, serum calcium was not significantly different from nonpregnant controls on day 12 and only slightly higher on day 15. Pseudopregnant rats were significantly hypercalcemic on days 12 (11.93 +/- 0.19 mg/dl) and 15 (11.45 +/- 0.23 mg/dl) compared with nonpregnant rats (P less than 0.001). In nonpregnant controls the serum level of 1,25(OH)2D3 was 44.6 +/- 6.3 pg/ml. Levels in pregnant rats were not significantly different on days 12 or 15 but tended to be higher by day 15 (75.2 +/- 19.7 pg/ml). Pseudopregnant rats had levels of 72.6 +/- 13.5 pg/ml on day 12 and 102.8 +/- 10.9 pg/ml on day 15, the latter of which was significantly higher than nonpregnant values (P less than 0.05). 25(OH)D3-1-hydroxylase activity was determined in whole tissue homogenates of placenta and decidua. Placenta from pregnant rats and decidua from pregnant and pseudopregnant rats both formed putative 1,25(OH)2D3 in short-term incubation with 25(OH)D3 as identified by comigration with authentic 1,25(OH)2D3 on high pressure liquid chromatography (HPLC).(ABSTRACT TRUNCATED AT 250 WORDS)
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