ArticleDevelopmental biology2019
Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.
Article in Developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic review and meta-analysis of the association between cyproterone acetate and intracranial meningiomas.Scientific reports · 2022Pooled it
- Expanding the phenotypic spectrum associated with ZIC1 variants: A neurodevelopmental disorder with and without craniosynostosis.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Mouse scalp development requires Rac1 and SRF for the maintenance of mechanoresponsive mesenchyme.Development (Cambridge, England) · 2025Article
- A spatially organizedScience advances · 2025Article
- Lamellipodia-Mediated Osteoblast Haptotaxis Guided by Fibronectin Ligand Concentrations on a Multiplex Chip.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.Development (Cambridge, England) · 2024Article
- A novel perspective of calvarial development: the cranial morphogenesis and differentiation regulated by dura mater.Frontiers in cell and developmental biology · 2024Review
- Stuck on you: Meninges cellular crosstalk in development.Current opinion in neurobiology · 2023Review
- Mechanisms of myeloid cell entry to the healthy and diseased central nervous system.Nature immunology · 2023Review
- Lineage-specific mutation ofFrontiers in physiology · 2023Article
- Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors.Cell reports · 2022Article
- R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development.Journal of developmental biology · 2021Article
- Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development.Journal of developmental biology · 2021Article
- Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme.Scientific reports · 2021Article
- Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease.Frontiers in cellular neuroscience · 2021Review
- Meningiomas from a developmental perspective: exploring the crossroads between meningeal embryology and tumorigenesis.Acta neurochirurgica · 2021Review
- Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.Developmental cell · 2020Article
- Where Did the Dura Mater Come from?Neurointervention · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to significant congenital defects in humans. It has been known that different areas of the cranial mesenchyme have different fates. For example, the calvarial bone develops from the cranial mesenchyme on the baso-lateral side of the head just above the eye (supraorbital mesenchyme, SOM), but not from the mesenchyme apical to SOM (early migrating mesenchyme, EMM). However, the molecular basis of this difference is not fully understood. To answer this question, we compared the transcriptomes of EMM and SOM using high-throughput sequencing (RNA-seq). This experiment identified a large number of genes that were differentially expressed in EMM and SOM, and gene ontology analyses found very different terms enriched in each region. We verified the expression of about 40 genes in the head by RNA in situ hybridization, and the expression patterns were annotated to make a map of molecular markers for 6 subdivisions of the cranial mesenchyme. Our data also provided insights into potential novel regulators of cranial mesenchyme development, including several axon guidance pathways, lectin complement pathway, cyclic-adenosine monophosphate (cAMP) signaling pathway, and ZIC family transcription factors. Together, information in this paper will serve as a unique resource to guide future research on cranial mesenchyme development.
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