ArticleArthritis care & research2020
Quality-Adjusted Life-Years Lost Due to Physical Inactivity in a US Population With Osteoarthritis.
Article in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Precision in practice: a systematic review and meta-analysis of virtual reality efficacy for osteoarthritis-specific total knee arthroplasty rehabilitation.BMC musculoskeletal disorders · 2026Pooled it
- Long-term physical activity in middle-aged patients with meniscal symptoms: a 10-year follow-up of a randomised controlled trial comparing exercise therapy alone to knee arthroscopic surgery plus exercise therapy.BMC musculoskeletal disorders · 2025Trial
- Chair stand performance and symptomatic knee osteoarthritis onset: a prospective cohort study.Rheumatology international · 2026Article
- Physical Function and Pain as Predictors of Movement Behaviors in Adults With Arthritis.American journal of health promotion : AJHP · 2026Article
- Experiences and perceptions of a 12-week combined exercise and dietary supplement program for individuals with knee osteoarthritis: a qualitative focus group study.BMC musculoskeletal disorders · 2026Article
- Dynapenic abdominal obesity and symptomatic knee osteoarthritis: results from a large cross-sectional study of middle-aged and older adults in China.Annals of joint · 2026Article
- Brisement Injection with Physical Therapy: A Novel Approach to Managing Glenohumeral Joint Osteoarthritis.International journal of sports physical therapy · 2025Article
- Combined knee osteoarthritis and diabetes is associated with reduced muscle strength, physical inactivity, and poorer quality of life.Journal of rehabilitation medicine · 2024Article
- Budget impact of the Walk With Ease program for knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Does Physical Activity Confound Race Differences in Osteoarthritis-Related Functional Limitation?Arthritis care & research · 2024Article
- Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities.Frontiers in endocrinology · 2024Review
- Knee osteoarthritis: disease burden, available treatments, and emerging options.Therapeutic advances in musculoskeletal disease · 2024Review
- Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study.Musculoskeletal care · 2023Article
- Walk with ease for knee osteoarthritis: A cost-effectiveness analysis.Osteoarthritis and cartilage open · 2023Article
- Osteoarthritis - Insights From Recent Research.Journal of rheumatic diseases · 2022Review
- Does Screening for Depressive Symptoms Help Optimize Duloxetine Use in Knee Osteoarthritis Patients With Moderate Pain? A Cost-Effectiveness Analysis.Arthritis care & research · 2022Article
- A tale of osteoarthritis among older adults during the COVID-19 pandemic in Bangladesh: A repeated cross-sectional study.PloS one · 2022Article
- Moving toward targeting the right phenotype with the right platelet-rich plasma (PRP) formulation for knee osteoarthritis.Therapeutic advances in musculoskeletal disease · 2021Review
- A comparison of three strategies to reduce the burden of osteoarthritis: A population-based microsimulation study.PloS one · 2021Article
- On the waiting list for joint replacement for knee osteoarthritis: Are first-line treatment recommendations implemented?Osteoarthritis and cartilage open · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveOne-half of the 14 million persons in the US with knee osteoarthritis (OA) are not physically active, despite evidence that physical activity (PA) is associated with improved health. We undertook this study to estimate both the quality-adjusted life-year (QALY) losses in a US population with knee OA due to physical inactivity and the health benefits associated with higher PA levels.
methodsWe used data from the Osteoarthritis Initiative and the Centers for Disease Control and Prevention to estimate the proportions of a US population with knee OA ages ≥45 years that are inactive, insufficiently active, and active, and the likelihood of a shift in their PA level. We used the OA Policy Model, a computer simulation of knee OA, to determine QALYs lost due to inactivity and to measure potential benefits of increased PA (comorbidities averted and QALYs saved).
resultsAmong 13.7 million persons with knee OA, a total of 7.5 million QALYs, or 0.55 QALYs per person, were lost due to inactivity or insufficient PA relative to activity over their remaining lifetimes. Black Hispanic women experienced the highest losses, at 0.76 QALYs per person. Women of all races/ethnicities had ~20% higher loss burdens than men. According to our model, if 20% of the inactive population were instead active, 95,920 cases of cancer, 222,413 of cardiovascular disease, and 214,725 of diabetes mellitus would potentially be averted, and 871,541 potential QALYs would be saved.
conclusionPhysical inactivity leads to substantial QALY losses in a US population with knee OA. Increases in the activity levels in even a fraction of this population may have considerable collateral health benefits, potentially averting cases of cancer, cardiovascular disease, and diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.