ReviewEndocrine2019
Thyroid hormone therapy in congenital hypothyroidism and pediatric hypothyroidism.
Review in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04734457 (Final Height in Patients With Congenital Hypothyroidism Diagnosed by Neonatal Screening), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Final Height in Patients With Congenital Hypothyroidism Diagnosed by Neonatal Screening
Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Comparative efficacy of early morning versus bedtime administration of levothyroxine in children with hypothyroidism: a prospective, open label, randomized, case-control study.Pediatric endocrinology, diabetes, and metabolism · 2021Trial
- Human thyroid organoids: tools for understanding thyroid diseases and development.Nature reviews. Endocrinology · 2026Review
- Stage-specific signaling modulation generates low-tumorigenicity thyroid progenitors from human pluripotent stem cells.Frontiers in endocrinology · 2026Article
- Progressive Impairment of Prepubertal Growth in Children With APECED.The Journal of clinical endocrinology and metabolism · 2025Article
- Unveiling the hidden: acquired pediatric hypothyroidism.Frontiers in endocrinology · 2025Review
- Revealing the genotype-phenotype correlations of congenital hypothyroidism in Yunnan Province, Southwest China.Frontiers in endocrinology · 2025Article
- Triiodothyronine levels in athyreotic pediatric patients during levothyroxine therapy.Frontiers in endocrinology · 2024Article
- Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration.Endocrinology · 2023Review
- Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism.Nature communications · 2022Article
- The role of miRNA-624-5p in congenital hypothyroidism and its molecular mechanism by targeting SIRT1.Genes & genomics · 2022Article
- Different combinations of monoclonal antibodies and polyclonal antibodies in the design of neonatal hypothyroidism diagnostic kit.Applied biochemistry and biotechnology · 2022Article
- Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity.Journal of clinical medicine · 2022Review
- Levothyroxine treatment for congenital hypothyroidism based on thyroid function: a 10-year clinical retrospective study.BMC endocrine disorders · 2022Article
- Expansion of Clinical and Genetic Spectrum ofFrontiers in molecular neuroscience · 2022Article
- Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height.The Journal of clinical endocrinology and metabolism · 2021Article
- Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.Cell death discovery · 2021Article
- Neonatal Dyshormonogenetic Goiter with Hypothyroidism Associated with Novel Mutations in Thyroglobulin and SLC26A4 Gene.Pediatric reports · 2021Article
- Anastrozole Improves Final Adult Height in Severe Hypothyroidism With Rapid Pubertal Progression.Journal of the Endocrine Society · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evaluation and management of hypothyroidism in children are similar to adults, but there are important differences based on the dependence on normal thyroid function for neurocognitive and physical development. In the pediatric population, hypothyroidism is frequently categorized as congenital or acquired hypothyroidism, depending on the age of presentation and the underlying etiology. The evaluation and management of children and adolescents with hypothyroidism are determined by the etiology as well as by the age at diagnosis, severity of the hypothyroidism, and the response to thyroid hormone replacement therapy. Children and adolescents require higher weight-based doses for thyroid hormone replacement than do adults, likely due to a shorter half-life of thyroxine (T4) and triiodothyronine (T3) in children, but weight-based dose requirements decrease as the child advances into adulthood. Multiple gaps in knowledge remains regarding how to optimize the treatment of hypothyroidism in pediatric patients, including (but not limited to) the selection of patients with subclinical hypothyroidism for treatment, and the potential benefit of combined LT3/LT4 therapy for patients with persistent symptoms and/or low T3 on LT4 monotherapy. The life-long impact on growth and development, and potentially on long-term cardiovascular and psychosocial health, are significant and highlight the importance of future prospective studies in pediatric patients to explore these areas of uncertainty.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.